Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Cash flows from operating activities
Net loss	$ (138,737)	$ (144,902)
Adjustments to reconcile net loss to net cash used in operating activities
Stock-based compensation expense	21,710	21,135
Depreciation and amortization	8,613	5,234
Net amortization of premiums on marketable debt securities	1,062	2,678
Net loss on investments		72
Imputed interest income from licensing	(110)	(247)
Non-cash interest expense	(1,236)	874
Other non-cash adjustments	(55)	308
Changes in operating assets and liabilities
Accounts receivable	7,108	(5,028)
Prepaid expenses	(1,212)	2,507
Other current assets	(12,846)	1,435
Operating lease right-of-use assets	2,806	2,017
Other assets	2,564	523
Accounts payable	(14,108)	9,527
Accrued expenses and other current liabilities	3,501	(25,593)
Deferred revenue	(1,212)	3,472
Operating lease liabilities	(3,345)	547
Other liabilities	(2,743)	7,781
Net cash used in operating activities	(128,240)	(117,660)
Cash flows from investing activities
Purchases of marketable debt securities	(49,795)	(158,360)
Maturities of marketable debt securities	175,502	86,892
Purchases of property and equipment	(7,395)	(20,204)
Net cash provided by (used in) investing activities	118,312	(91,672)
Cash flows from financing activities
Proceeds from exercise of stock options	1,220	1,844
Taxes paid related to net settlement of stock-based awards	(419)	(284)
Proceeds from issuance of common stock under employee stock purchase plan	583	622
Repayments under liability related to sale of future royalties, net of imputed interest	(19,583)	(16,685)
Net cash used in financing activities	(18,199)	(14,503)
Net decrease in cash and cash equivalents and restricted cash	(28,127)	(223,835)
Cash and cash equivalents and restricted cash
Beginning of period	98,982	347,239
End of period	$ 70,855	$ 123,404