Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Revenues
Revenues	$ 19,977	$ 32,649	$ 39,115	$ 54,867
Operating Expenses
Cost of revenues	9,475	12,951	13,587	28,668
Research and development	59,886	61,008	118,402	116,635
General and administrative	23,698	20,832	46,332	43,150
Other operating expenses	26	391	59	474
Total operating expenses	93,085	95,182	178,380	188,927
Loss from operations	(73,108)	(62,533)	(139,265)	(134,060)
Other Income (Expense)
Interest income from licensing	40	153	110	247
Investment income	2,127	1,061	4,293	1,860
Interest expense	(1,120)	(6,860)	(3,875)	(12,990)
Total other income (expense)	1,047	(5,646)	528	(10,883)
Loss before income taxes	(72,061)	(68,179)	(138,737)	(144,943)
Income Tax Benefit				41
Net loss	(72,061)	(68,179)	(138,737)	(144,902)
Other Comprehensive Income (Loss)
Unrealized gain (loss) on available-for-sale securities, net	1,524	(2,813)	5,303	(12,194)
Total other comprehensive income (loss)	1,524	(2,813)	5,303	(12,194)
Comprehensive loss	$ (70,537)	$ (70,992)	$ (133,434)	$ (157,096)
Net loss per share, basic	$ (1.66)	$ (1.58)	$ (3.19)	$ (3.37)
Net loss per share, diluted	$ (1.66)	$ (1.58)	$ (3.19)	$ (3.37)
Weighted-average common shares outstanding, basic	43,531	43,111	43,491	43,028
Weighted-average common shares outstanding, diluted	43,531	43,111	43,491	43,028
License and royalty [Member]
Revenues
Revenues	$ 19,977	$ 32,649	$ 39,115	$ 54,867