Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Cash flows from operating activities
Net loss	$ (66,676)	$ (76,723)
Adjustments to reconcile net loss to net cash used in operating activities
Stock-based compensation expense	11,206	10,800
Depreciation and amortization	4,178	2,591
Net amortization of premiums on marketable debt securities	682	1,460
Imputed interest income from licensing	(70)	(94)
Non-cash interest expense	(574)	54
Other non-cash adjustments	(52)	(43)
Changes in operating assets and liabilities
Accounts receivable	9,495	5,689
Prepaid expenses	(1,621)	210
Other current assets	(13,651)	3,042
Operating lease right-of-use assets	1,390	979
Other assets	(1,893)	(2,101)
Accounts payable	(3,103)	16,755
Accrued expenses and other current liabilities	(15,443)	(26,473)
Deferred revenue	(433)
Operating lease liabilities	(1,504)	1,008
Other liabilities	(2,849)	6,935
Net cash used in operating activities	(80,918)	(55,911)
Cash flows from investing activities
Purchases of marketable debt securities		(129,486)
Maturities of marketable debt securities	67,912	49,862
Purchases of property and equipment	(4,818)	(10,967)
Net cash provided by (used in) investing activities	63,094	(90,591)
Cash flows from financing activities
Proceeds from exercise of stock options	471	337
Taxes paid related to net settlement of stock-based awards	(419)	(284)
Proceeds from issuance of common stock under employee stock purchase plan	583	622
Repayments under liability related to sale of future royalties, net of imputed interest	(9,672)	(7,509)
Net cash used in financing activities	(9,037)	(6,834)
Net decrease in cash and cash equivalents and restricted cash	(26,861)	(153,336)
Cash and cash equivalents and restricted cash
Beginning of period	98,982	347,239
End of period	$ 72,121	$ 193,903