Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Revenues
Revenues	$ 19,138	$ 22,218
Operating Expenses
Cost of revenues	4,112	15,717
Research and development	58,516	55,627
General and administrative	22,634	22,318
Other operating expenses	33	83
Total operating expenses	85,295	93,745
Loss from operations	(66,157)	(71,527)
Other Income (Expense)
Interest income from licensing	70	94
Investment income	2,166	799
Interest expense	(2,755)	(6,130)
Total other income (expense)	(519)	(5,237)
Loss before income taxes	(66,676)	(76,764)
Income Tax Benefit		41
Net loss	(66,676)	(76,723)
Other Comprehensive Income (Loss)
Unrealized gain (loss) on available-for-sale securities, net	3,779	(9,381)
Total other comprehensive income (loss)	3,779	(9,381)
Comprehensive loss	$ (62,897)	$ (86,104)
Net loss per share, basic	$ (1.53)	$ (1.79)
Net loss per share, diluted	$ (1.53)	$ (1.79)
Weighted-average common shares outstanding, basic	43,451	42,944
Weighted-average common shares outstanding, diluted	43,451	42,944
License and royalty [Member]
Revenues
Revenues	$ 19,138	$ 22,218