Income Taxes - Components of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Deferred tax assets:
Net operating loss carryforwards	$ 25,435	$ 3,981
Research and development tax credits	62,545	45,576
Stock-based compensation	21,770	18,303
Lease liabilities	27,085	23,430
Liability related sale of future royalties	35,711	43,234
Capitalized research and development costs	74,989
Accruals and other	11,673	6,230
Total deferred tax assets before valuation allowance	259,208	140,754
Valuation allowance	(211,150)	(110,756)
Total deferred tax assets	48,058	29,998
Deferred tax liabilities:
Right-of-use assets	(18,571)	(16,363)
Depreciation and amortization	(29,487)	(13,635)
Total deferred tax liabilities	$ (48,058)	$ (29,998)