Income Taxes - Schedule of Reconciliation of Effective Income Tax Expense (Benefit) (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Income Tax Disclosure [Abstract]
Federal income tax expense (benefit) at statutory rate	$ (58,885)	$ 29,662	$ (22,263)
State income tax expense (benefit), net of federal tax effect	(22,743)	9,183	(11,495)
Research and development credits	(16,844)	(10,059)	(7,793)
Stock-based compensation	3,216	755	587
Executive compensation	1,839	1,511	202
Other non-deductible expenses and reconciling items	241	329	684
Change in corporate tax rates	(3,636)	14,772	109
Change in valuation allowance	96,728	(32,746)	45,209
Total income tax expense (benefit)	$ (84)	$ 13,407	$ 5,240