Consolidated Statements of Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands	Total	Common Stock [Member]	Additional paid in capital [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated Deficit [Member]
Balances at Dec. 31, 2019	$ 450,197	$ 4	$ 627,810	$ 205	$ (177,822)
Balances (Shares) at Dec. 31, 2019		36,992
Issuance of common stock under employee stock purchase plan, shares		55
Issuance of common stock under employee stock purchase plan	1,799		1,799
Stock-based compensation expense	31,949		31,949
Unrealized loss on available-for-sale securities, net	(565)			(565)
Exercise of stock options, Shares		428
Exercise of stock options	5,623		5,623
Net income (loss)	(111,250)				(111,250)
Balances at Dec. 31, 2020	377,753	$ 4	667,181	(360)	(289,072)
Balances (Shares) at Dec. 31, 2020		37,476
Issuance of common stock under employee stock purchase plan, shares		54
Issuance of common stock under employee stock purchase plan	1,768		1,768
Stock-based compensation expense	38,808		38,808
Unrealized loss on available-for-sale securities, net	(2,209)			(2,209)
Issuance of common stock upon public offering, net of transaction costs	216,059		216,059
Exercise of stock options, Shares		403
Exercise of stock options	4,279		4,279
Issuance of stock, net of transaction costs		4,899
Net income (loss)	127,840				127,840
Balances at Dec. 31, 2021	764,298	$ 4	928,095	(2,569)	(161,232)
Balances (Shares) at Dec. 31, 2021		42,831
Issuance of common stock under employee stock purchase plan, shares		76
Issuance of common stock under employee stock purchase plan	1,742		1,742
Stock-based compensation expense	40,788		40,788
Unrealized loss on available-for-sale securities, net	(12,832)			(12,832)
Exercise of stock options, Shares		332
Exercise of stock options	2,804		2,804
Vesting of restricted stock units, net of tax	(284)		(284)
Vesting of restricted stock units, net of tax, Shares		60
Net income (loss)	(280,321)				(280,321)
Balances at Dec. 31, 2022	$ 516,195	$ 4	$ 973,145	$ (15,401)	$ (441,553)
Balances (Shares) at Dec. 31, 2022		43,299