Consolidated Statements of Operations and Comprehensive Income (Loss) - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenues
Revenues	$ 112,724	$ 470,347	$ 154,567
Operating Expenses
Cost of revenues	54,545	51,833	35,714
Research and development	242,453	181,437	166,294
General and administrative	85,281	79,333	63,817
Credit losses (recoveries)	0	(2,569)	7,678
Other operating expenses (income)	(6,679)	333	297
Total operating expenses	375,600	310,367	273,800
Income (loss) from operations	(262,876)	159,980	(119,233)
Other Income (Expense)
Interest income from licensing	342	719	4,271
Investment income	5,383	6,825	9,723
Interest expense	(23,254)	(26,277)	(771)
Total other income (expense)	(17,529)	(18,733)	13,223
Income (loss) before income taxes	(280,405)	141,247	(106,010)
Income Tax Benefit (Expense)	84	(13,407)	(5,240)
Net income (loss)	(280,321)	127,840	(111,250)
Other Comprehensive Loss
Unrealized loss on available-for-sale securities, net	(12,832)	(2,209)	(565)
Total other comprehensive loss	(12,832)	(2,209)	(565)
Comprehensive income (loss)	$ (293,153)	$ 125,631	$ (111,815)
Earnings Per Share [Abstract]
Basic	$ (6.50)	$ 3.01	$ (2.98)
Diluted	$ (6.50)	$ 2.91	$ (2.98)
Weighted-average common shares outstanding:
Basic	43,152	42,438	37,281
Diluted	43,152	43,913	37,281
License and royalty [Member]
Revenues
Revenues	$ 112,724	$ 470,347	$ 154,567