CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS’ EQUITY - USD ($) $ in Thousands	Total	Public Offering	Series A Preferred Stock	Series B Preferred Stock	Preferred Stock Series A Preferred Stock	Preferred Stock Series B Preferred Stock	Preferred Stock Series B Preferred Stock Public Offering	Common Stock	Common Stock Public Offering	Additional Paid-in Capital	Additional Paid-in Capital Public Offering	Accumulated Other Comprehensive Loss	Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2021					260,437	23,126
Beginning balance at Dec. 31, 2021	$ 187,716				$ 118,164	$ 15,669		$ 239		$ 412,101		$ (157)	$ (358,300)
Beginning balance (in shares) at Dec. 31, 2021								23,924,004
Stockholders’ deficit
Issuance of common stock upon the conversion of convertible preferred stock (in shares)					(47,871)			3,191,555
Issuance of common stock upon the conversion of convertible preferred stock	0				$ (21,722)			$ 33		21,689
Issuance of common stock for exercises of stock options (in shares)								47,735
Issuance of common stock for exercises of stock options	667									667
Issuance of common stock for cash under employee stock purchase plan (in shares)								6,128
Issuance of common stock for cash under employee stock purchase plan	71									71
Share-based compensation expense	4,659									4,659
Change in unrealized gain (loss) on investments	(778)											(778)
Net loss	(25,693)												(25,693)
Ending balance (in shares) at Mar. 31, 2022					212,566	23,126
Ending balance at Mar. 31, 2022	166,642				$ 96,442	$ 15,669		$ 272		439,187		(935)	(383,993)
Ending balance (in shares) at Mar. 31, 2022								27,169,422
Beginning balance (in shares) at Dec. 31, 2021					260,437	23,126
Beginning balance at Dec. 31, 2021	187,716				$ 118,164	$ 15,669		$ 239		412,101		(157)	(358,300)
Beginning balance (in shares) at Dec. 31, 2021								23,924,004
Stockholders’ deficit
Change in unrealized gain (loss) on investments	(783)
Net loss	(84,089)
Ending balance (in shares) at Sep. 30, 2022					188,381	51,210
Ending balance at Sep. 30, 2022	409,007				$ 85,470	$ 56,677		$ 402		709,787		(940)	(442,389)
Ending balance (in shares) at Sep. 30, 2022								40,244,355
Beginning balance (in shares) at Mar. 31, 2022					212,566	23,126
Beginning balance at Mar. 31, 2022	166,642				$ 96,442	$ 15,669		$ 272		439,187		(935)	(383,993)
Beginning balance (in shares) at Mar. 31, 2022								27,169,422
Stockholders’ deficit
Issuance of common stock upon the conversion of convertible preferred stock (in shares)					(19,027)			1,268,528
Issuance of common stock upon the conversion of convertible preferred stock	0				$ (8,633)			$ 13		8,620
Issuance of common stock for exercises of stock options (in shares)								26,030
Issuance of common stock for exercises of stock options	4									4
Share-based compensation expense	4,885									4,885
Change in unrealized gain (loss) on investments	(142)											(142)
Net loss	(29,491)												(29,491)
Ending balance (in shares) at Jun. 30, 2022					193,539	23,126
Ending balance at Jun. 30, 2022	141,898				$ 87,809	$ 15,669		$ 285		452,696		(1,077)	(413,484)
Ending balance (in shares) at Jun. 30, 2022								28,463,980
Stockholders’ deficit
Issuance of common stock upon the conversion of convertible preferred stock (in shares)					(5,158)			343,882
Issuance of common stock upon the conversion of convertible preferred stock	0				$ (2,339)			$ 2		2,337
Issuance of common stock upon exercises of warrants (in shares)								56,666
Issuance of common stock upon exercises of warrants	935							$ 1		934
Issuance of common stock for exercises of stock options (in shares)								20,291
Issuance of common stock for exercises of stock options	237									237
Issuance of common stock for cash under employee stock purchase plan (in shares)								6,896
Issuance of common stock for cash under employee stock purchase plan	112									112
Issuance of stock, net of issuance costs (in shares)							28,084		11,352,640
Issuance of stock, net of issuance costs		$ 289,650					$ 41,008		$ 114		$ 248,528
Share-based compensation expense	4,943									4,943
Change in unrealized gain (loss) on investments	137											137
Net loss	(28,905)												(28,905)
Ending balance (in shares) at Sep. 30, 2022					188,381	51,210
Ending balance at Sep. 30, 2022	409,007				$ 85,470	$ 56,677		$ 402		709,787		(940)	(442,389)
Ending balance (in shares) at Sep. 30, 2022								40,244,355
Beginning balance (in shares) at Dec. 31, 2022			188,381	51,210	188,381	51,210
Beginning balance at Dec. 31, 2022	$ 395,064				$ 85,470	$ 56,677		$ 414		741,067		(390)	(488,174)
Beginning balance (in shares) at Dec. 31, 2022	41,305,947							41,305,947
Stockholders’ deficit
Issuance of common stock upon the conversion of convertible preferred stock (in shares)					(15,946)			1,063,118
Issuance of common stock upon the conversion of convertible preferred stock	$ 0				$ (7,235)			$ 10		7,225
Issuance of common stock upon exercises of warrants (in shares)								57,553
Issuance of common stock upon exercises of warrants	946							$ 1		945
Issuance of common stock for exercises of stock options (in shares)								612,846
Issuance of common stock for exercises of stock options	6,938							$ 6		6,932
Issuance of common stock for cash under employee stock purchase plan (in shares)								15,854
Issuance of common stock for cash under employee stock purchase plan	320									320
Share-based compensation expense	15,216									15,216
Change in unrealized gain (loss) on investments	216											216
Net loss	(68,151)												(68,151)
Ending balance (in shares) at Mar. 31, 2023					172,435	51,210
Ending balance at Mar. 31, 2023	350,549				$ 78,235	$ 56,677		$ 431		771,705		(174)	(556,325)
Ending balance (in shares) at Mar. 31, 2023								43,055,318
Beginning balance (in shares) at Dec. 31, 2022			188,381	51,210	188,381	51,210
Beginning balance at Dec. 31, 2022	$ 395,064				$ 85,470	$ 56,677		$ 414		741,067		(390)	(488,174)
Beginning balance (in shares) at Dec. 31, 2022	41,305,947							41,305,947
Stockholders’ deficit
Change in unrealized gain (loss) on investments	$ 326
Net loss	(170,874)
Ending balance (in shares) at Sep. 30, 2023			172,435	51,210	172,435	51,210
Ending balance at Sep. 30, 2023	$ 283,576				$ 78,235	$ 56,677		$ 437		807,339		(64)	(659,048)
Ending balance (in shares) at Sep. 30, 2023	43,700,989							43,700,989
Beginning balance (in shares) at Mar. 31, 2023					172,435	51,210
Beginning balance at Mar. 31, 2023	$ 350,549				$ 78,235	$ 56,677		$ 431		771,705		(174)	(556,325)
Beginning balance (in shares) at Mar. 31, 2023								43,055,318
Stockholders’ deficit
Issuance of common stock upon exercises of warrants (in shares)								56,666
Issuance of common stock upon exercises of warrants	935							$ 1		934
Issuance of common stock for exercises of stock options (in shares)								245,381
Issuance of common stock for exercises of stock options	2,133							$ 2		2,131
Issuance of common stock under license agreement (in shares)								204,843
Issuance of common stock under license agreement	5,000							$ 2		4,998
Share-based compensation expense	12,302									12,302
Change in unrealized gain (loss) on investments	1											1
Net loss	(55,063)												(55,063)
Ending balance (in shares) at Jun. 30, 2023					172,435	51,210
Ending balance at Jun. 30, 2023	315,857				$ 78,235	$ 56,677		$ 436		792,070		(173)	(611,388)
Ending balance (in shares) at Jun. 30, 2023								43,562,208
Stockholders’ deficit
Issuance of common stock for exercises of stock options (in shares)								84,360
Issuance of common stock for exercises of stock options	711							$ 1		710
Issuance of common stock for cash under employee stock purchase plan (in shares)								15,362
Issuance of common stock for cash under employee stock purchase plan	260									260
Issuance of common stock under license agreement (in shares)								39,059
Issuance of common stock under license agreement	693									693
Share-based compensation expense	13,606									13,606
Change in unrealized gain (loss) on investments	109											109
Net loss	(47,660)												(47,660)
Ending balance (in shares) at Sep. 30, 2023			172,435	51,210	172,435	51,210
Ending balance at Sep. 30, 2023	$ 283,576				$ 78,235	$ 56,677		$ 437		$ 807,339		$ (64)	$ (659,048)
Ending balance (in shares) at Sep. 30, 2023	43,700,989							43,700,989