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SHARE-BASED COMPENSATION (Tables)
 9 Months Ended
Sep. 30, 2023
Share-Based Payment Arrangement [Abstract]  
Schedule of Summary of Balances by Plan As of September 30, 2023, the Company had the following balances by plan:
Restricted Stock Units OutstandingStock Options OutstandingShares Available for Issuance
Inducement Awards250,000 3,719,757 — 
2020 Plan— 483,927 — 
2016 Plan88,875 4,057,422 4,576,697 
2008 Plan— 155 — 
    Total338,875 8,261,261 4,576,697 
Schedule of Stock Option Activity
A summary of common stock option activity is as follows:
Number of OptionsWeighted-Average Exercise PriceWeighted-Average Remaining Contractual Term
(years)		Aggregate Intrinsic Value
(in thousands)
Outstanding as of December 31, 2022
5,722,449 $17.238.64$68,977 
Granted4,600,250 $31.07
Exercised(942,587)$10.38
Forfeited or expired(1,118,851)$21.40
Outstanding as of September 30, 2023
8,261,261 $25.158.31$4,004 
Vested and expected to vest as of September 30, 2023
8,261,261 $25.158.31$4,004 
Exercisable as of September 30, 2023
2,490,556 $20.096.41$2,168 
Vested as of September 30, 2023
2,490,556 $20.096.41$2,168 
Schedule of Fair Value Assumptions for Stock Options The fair value was determined by the Black-Scholes option pricing model using the following weighted-average assumptions:
Nine Months Ended September 30,
20232022
Expected term, in years5.575.81
Expected volatility90.8%88.1%
Risk-free interest rate3.8%2.3%
Expected dividend yield—%—%
Weighted average exercise price$31.07$16.35
Schedule of Allocation of Share-based Compensation Expense
Share-based compensation related to all equity awards issued pursuant to the Equity Incentive Plans and the Inducement Plan, and for shares to be issued under the ESPP for the purchase periods active during each respective period is included in the condensed consolidated statements of operations and comprehensive loss as follows:
Three Months Ended September 30,
Nine Months Ended September 30,
2023202220232022
(in thousands)
Research and development$4,003 $1,884 $11,671 $5,220 
General and administrative9,603 3,059 29,453 9,267 
    Total share-based compensation expense$13,606 $4,943 $41,124 $14,487