X0306 4/A 2020-09-13 2020-09-15 0 0001590750 MIRAGEN THERAPEUTICS, INC. MGEN 0001815345 Rauch Lee M. C/O MIRAGEN THERAPEUTICS, INC. 6200 LOOKOUT ROAD BOULDER CO 80301 1 1 0 0 President & CEO Stock Option (right to buy) 0.9087 2020-09-13 4 A 0 900000 0.00 A 2020-10-13 2020-09-12 Common Stock 900000 900000 D This amended Form 4 is being filed to correct the date of grant and related terms. Grant to the Reporting Person of a stock option under the Issuer's 2016 Equity Incentive Plan (the "Plan"). The shares vest in 48 equal monthly installments beginning on October 13, 2020, provided that at the relevant vesting dates the Reporting Person's continuous service to the Issuer has not been terminated as defined in and as determined under the Plan. The shares underlying the option are subject to accelerated vesting upon the occurrence of specified events including a change of control of the Issuer and the Reporting Person's termination. The option expires ten years after the date of grant. /s/ Brent D. Fassett, as Attorney-in-Fact for Lee M. Rauch 2020-09-17