X0306 4 2018-01-03 0 0001590750 MIRAGEN THERAPEUTICS, INC. MGEN 0001611048 Hughes Thomas E. C/O MIRAGEN THERAPEUTICS, INC. 6200 LOOKOUT ROAD BOULDER CO 80301 1 0 0 0 Stock Option (right to buy) 9.72 2018-01-03 2018-01-03 4 A 0 3426 0.00 A 2028-01-02 Common Stock 3426 3426 D Grant to the Reporting Person of a stock option under the Issuer's 2016 Equity Incentive Plan (the "Plan"). The shares vest in four equal quarterly installments beginning on January 1, 2018 through December 31, 2018, provided that at the relevant vesting dates the Reporting Person's continuous service to the Issuer has not been terminated as defined in and as determined under the Plan. The option expires 10 years after the date of grant. /s/ Kassendra Galindo as Attorney-in-Fact for Thomas E. Hughes 2018-01-05