X0306 4 2016-10-31 0 0001590750 SIGNAL GENETICS, INC. SGNL 0001288232 SEYMOUR TAMARA A C/O SIGNAL GENETICS, INC. 5740 FLEET STREET CARLSBAD CA 92008 0 1 0 0 CFO, Secretary, Treasurer Common Stock 2016-10-31 4 M 0 46000 A 72994 I By Trust Common Stock 2016-10-31 4 F 0 20967 0.36 D 52027 I By Trust Common Stock 2016-10-31 4 M 0 100000 A 152027 I By Trust Common Stock 2016-10-31 4 F 0 45580 0.36 D 106447 I By Trust Restricted Stock Units 2016-10-31 4 M 0 46000 0.00 D Common Stock 46000 0 D Restricted Stock Units 2016-10-31 4 M 0 100000 0.00 D Common Stock 100000 0 D Restricted stock units converted into common stock on a one-for-one basis. Shares withheld to satisfy tax withholding obligations. On August 4, 2014, the reporting person was granted 92,000 restricted stock units. In connection with the execution of the Agreement and Plan of Merger and Reorganization, dated October 31, 2016, by and among Signal Genetics, Inc. (the "Issuer"), Signal Merger Sub, Inc. and Miragen Therapeutics, Inc. (the "Merger Agreement"), the Compensation Committee of the Issuer's Board of Directors accelerated the vesting of the remaining 46,000 restricted stock units in full. On March 28, 2016, the reporting person was granted 100,000 restricted stock units. In connection with the execution of the Merger Agreement, the Compensation Committee of the Issuer's Board of Directors accelerated the vesting of these restricted stock units in full. /s/Samuel D. Riccitelli, as Attorney-in-Fact for Tamara A. Seymour 2016-11-02