X0306 4 2016-10-31 0 0001590750 SIGNAL GENETICS, INC. SGNL 0001414839 Riccitelli Samuel D C/O SIGNAL GENETICS, INC. 5740 FLEET STREET CARLSBAD CA 92008 1 1 0 0 President & CEO Common Stock 2016-10-31 4 M 0 200000 0.00 A 674530 D Common Stock 2016-10-31 4 F 0 103160 0.36 D 571370 D Restricted Stock Units 0.00 2016-10-31 4 M 0 200000 0.00 D Common Stock 200000 0 D The restricted stock units reported herein converted into common stock on a one-for-one basis. Shares withheld to satisfy tax withholding obligations. On March 28, 2016, the reporting person was granted 200,000 restricted stock units. In connection with the execution of the Agreement and Plan of Merger and Reorganization, dated October 31, 2016, by and among Signal Genetics, Inc. (the "Issuer"), Signal Merger Sub, Inc. and Miragen Therapeutics, Inc. (the "Merger Agreement"), the Compensation Committee of the Issuer's Board of Directors accelerated the vesting of these restricted stock units in full. /s/Samuel D. Riccitelli 2016-11-02