X0306 4 2016-03-28 0 0001590750 SIGNAL GENETICS, INC. SGNL 0001288232 SEYMOUR TAMARA A C/O SIGNAL GENETICS, INC. 5740 FLEET STREET CARLSBAD CA 92008 0 1 0 0 CFO, Secretary, Treasurer Restricted Stock Units 0.00 2016-03-28 4 A 0 100000 0.00 A 2026-03-28 Common Stock 100000 100000 D Each Restricted Stock Unit represents the contingent right to receive the economic equivalent of one share of the Issuer's common stock, payable in shares of common stock, cash or some combination of both, as determined by the Issuer. The Restricted Stock Unit vests 25% on March 28, 2017 and 6.25% of the remaining number of shares vests quarterly thereafter on each of the following 12 quarters, subject to the Reporting Person's continuous service to the Issuer on each such date. /s/Samuel D. Riccitelli, as Attorney-in-Fact for Tamara A. Seymour 2016-05-19