CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash flows from operating activities
Net (loss) / income	$ (133,596)	$ 321,381
Adjustments to reconcile net (loss) / income to net cash (used in) / generated from operating activities:
Depreciation and amortization expense	6,206	5,447
Share-based compensation expense	22,290	18,747
Deferred tax (income) / expense	(1,263)	3,560
Changes in fair value of contingent consideration and derivative financial instrument, net	6,875	416
Unrealized foreign exchange gains, net	(36,390)	(23,242)
Other non-current assets, net	(581)	(2,862)
Changes in operating assets and liabilities:
Accounts receivable and contract asset, prepaid expenses, and other current assets and receivables	41,992	(1,993)
Inventories	(4,075)
Accounts payable	4,529	2,003
Accrued expenses, other liabilities, and operating leases	3,633	11,592
Net cash (used in) / generated from operating activities	(90,380)	335,049
Cash flows from investing activities
Purchases of property, plant, and equipment	(12,622)	(13,885)
Acquisition of Corlieve, net of cash acquired	(1,900)	(49,949)
Net cash used in investing activities	(14,522)	(63,834)
Cash flows from financing activities
Proceeds from issuance of ordinary shares related to employee stock option and purchase plans	844	1,971
Proceeds from loan increment, net of debt issuance costs		34,603
Proceeds from issuance of ordinary shares		30,899
Share issuance costs from issuance of ordinary shares		(1,334)
Repayment of debt acquired through acquisition of Corlieve		(1,175)
Net cash generated from financing activities	844	64,964
Currency effect on cash, cash equivalents and restricted cash	(11,876)	(2,589)
Net (decrease) / increase in cash, cash equivalents and restricted cash	(115,934)	333,590
Cash, cash equivalents and restricted cash at beginning of period	559,353	247,680
Cash, cash equivalents and restricted cash at the end of period	443,419	581,270
Cash and cash equivalents	440,313	578,464
Restricted cash related to leasehold and other deposits	3,106	2,806
Total cash, cash equivalents and restricted cash	443,419	581,270
Supplemental cash flow disclosures:
Cash paid for interest	(6,410)	(4,503)
Non-cash (decrease) / increase in accounts payables and accrued expenses and other current liabilities related to purchases of property, plant, and equipment	$ 1,766	$ 415