CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE (LOSS) INCOME - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Total revenues	$ 1,449	$ 1,989	$ 3,738	$ 466,311
Operating expenses:
Cost of contract revenues				(23,178)
Cost of contract manufacturing	(861)		(1,693)
Research and development expenses	(48,068)	(36,432)	(139,263)	(101,209)
Selling, general and administrative expenses	(13,324)	(12,023)	(36,802)	(42,323)
Total operating expenses	(62,253)	(48,455)	(177,758)	(166,710)
Other income	1,485	1,680	4,981	9,622
Other expense	(199)	(214)	(621)	(673)
(Loss) / income from operations	(59,518)	(45,000)	(169,660)	308,550
Interest income	39	46	117	123
Interest expense	(3,069)	(1,924)	(8,279)	(5,377)
Foreign currency gains, net	14,362	10,436	42,328	21,645
Other non-operating (losses) / gains, net			635
(Loss) / income before income tax benefit / (expense)	(48,186)	(36,442)	(134,859)	324,941
Income tax benefit / (expense)	329	(89)	1,263	(3,560)
Net (loss) / income	(47,857)	(36,531)	(133,596)	321,381
Other comprehensive loss:
Foreign currency translation adjustments	(25,370)	(13,288)	(64,144)	(27,790)
Total comprehensive (loss) / gain	$ (73,227)	$ (49,819)	$ (197,740)	$ 293,591
Earnings per ordinary share - basic
Basic net (loss) / income per ordinary share	$ (1.02)	$ (0.79)	$ (2.86)	$ 7.00
Earnings per ordinary share - diluted
Diluted net (loss) / income per ordinary share	$ (1.02)	$ (0.79)	$ (2.86)	$ 6.87
Weighted average shares - basic	46,772,430	46,152,404	46,680,667	45,888,769
Weighted average shares - diluted	46,772,430	46,152,404	46,680,667	46,780,963
License revenues
Total revenues				$ 462,400
Collaboration revenues
Total revenues	$ 1,449	$ 1,989	$ 3,738	$ 3,911