CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Current assets
Cash and cash equivalents	$ 440,313	$ 556,256
Accounts receivable and contract asset	3,603	58,768
Inventories	4,075
Prepaid expenses	13,692	10,540
Other current assets and receivables	2,894	2,675
Total current assets	464,577	628,239
Non-current assets
Property, plant and equipment, net of accumulated depreciation of $40.5 million as of September 30, 2022 and $36.9 million as of December 31, 2021	47,886	43,505
Operating lease right-of-use assets	27,804	25,573
Intangible assets, net, including an in-process research and development asset of $52.5 million as of September 30, 2022 and $60.8 million as of December 31, 2021	53,837	62,686
Goodwill	23,418	27,633
Deferred tax assets, net	14,627	15,647
Other non-current assets	6,085	5,897
Total non-current assets	173,657	180,941
Total assets	638,234	809,180
Current liabilities
Accounts payable	7,566	2,502
Accrued expenses and other current liabilities	26,437	28,487
Current portion of contingent consideration	23,537
Current portion of operating lease liabilities	6,434	5,774
Total current liabilities	63,974	36,763
Non-current liabilities
Long-term debt	102,394	100,963
Operating lease liabilities, net of current portion	29,893	28,987
Contingent consideration, net of current portion	9,158	29,542
Deferred tax liability, net	8,592	12,913
Other non-current liabilities	3,053	4,236
Total non-current liabilities	153,090	176,641
Total liabilities	217,064	213,404
Commitments and contingencies
Shareholders' equity
Ordinary shares, €0.05 par value: 80,000,000 shares authorized as of September 30, 2022 and December 31, 2021 and 46,815,109 and 46,298,635 ordinary shares issued and outstanding as of September 30, 2022 and December 31, 2021, respectively	2,830	2,802
Additional paid-in-capital	1,100,078	1,076,972
Accumulated other comprehensive loss	(93,000)	(28,856)
Accumulated deficit	(588,738)	(455,142)
Total shareholders' equity	421,170	595,776
Total liabilities and shareholders' equity	$ 638,234	$ 809,180