CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities
Net (loss) / income	$ (85,739)	$ 357,912
Adjustments to reconcile net (loss) / income to net cash (used in) / generated from operating activities:
Depreciation and amortization expense	4,103	3,667
Share-based compensation expense	14,682	12,792
Deferred tax (income) / expense	(934)	3,471
Changes in fair value of contingent consideration and derivative financial instrument, net	1,371
Unrealized foreign exchange gains, net	(24,491)	(12,279)
Other non-cash items, net	(257)	(2,932)
Changes in operating assets and liabilities:
Accounts receivable and contract asset, prepaid expenses, and other current assets and receivables	46,492	(3,355)
Inventories	(2,949)
Accounts payable	7,632	10,444
Accrued expenses, other liabilities, and operating leases	(1,299)	5,486
Net cash (used in) / generated from operating activities	(41,389)	375,206
Cash flows from investing activities
Purchases of property, plant, and equipment	(8,637)	(6,191)
Acquisition of remaining outstanding ordinary shares related to Corlieve acquisition	(822)
Net cash used in investing activities	(9,459)	(6,191)
Cash flows from financing activities
Proceeds from issuance of ordinary shares related to employee stock option and purchase plans	543	960
Proceeds from loan increment, net of debt issuance costs		34,603
Proceeds from issuance of ordinary shares		30,899
Share issuance costs from issuance of ordinary shares		(1,334)
Net cash generated from financing activities	543	65,128
Currency effect on cash, cash equivalents and restricted cash	(5,382)	(1,665)
Net (decrease) / increase in cash, cash equivalents and restricted cash	(55,687)	432,478
Cash, cash equivalents and restricted cash at beginning of period	559,353	247,680
Cash, cash equivalents and restricted cash at the end of period	503,666	680,158
Cash and cash equivalents	500,524	677,330
Restricted cash related to leasehold and other deposits	3,142	2,828
Total cash, cash equivalents and restricted cash	503,666	680,158
Supplemental cash flow disclosures:
Cash paid for interest	(3,980)	(2,943)
Non-cash (decrease) / increase in accounts payables and accrued expenses and other current liabilities related to purchases of property, plant, and equipment	$ (277)	$ 3,488