CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Total revenues	$ 497	$ 463,868	$ 2,289	$ 464,322
Operating expenses:
Cost of contract revenues		(23,178)		(23,178)
Cost of manufacturing services revenues	(832)		(832)
Research and development expenses	(46,192)	(32,747)	(91,195)	(64,777)
Selling, general and administrative expenses	(12,491)	(17,299)	(23,478)	(30,300)
Total operating expenses	(59,515)	(73,224)	(115,505)	(118,255)
Other income	3,186	7,590	3,496	7,942
Other expense	(229)	(226)	(422)	(459)
(Loss) / income from operations	(56,061)	398,008	(110,142)	353,550
Interest income	35	37	78	77
Interest expense	(2,694)	(1,902)	(5,210)	(3,453)
Foreign currency gains, net	19,398	6,583	27,966	11,209
Other non-operating (losses) / gains, net	(57)		635
(Loss) / income before income tax benefit / (expense)	(39,379)	402,726	(86,673)	361,383
Income tax benefit / (expense)	318	(3,258)	934	(3,471)
Net (loss) / income	(39,061)	399,468	(85,739)	357,912
Other comprehensive loss:
Foreign currency translation adjustments	(28,324)	(6,942)	(38,774)	(14,502)
Total comprehensive (loss) / gain	$ (67,385)	$ 392,526	$ (124,513)	$ 343,410
Earnings per ordinary share - basic
Basic net (loss) / income per ordinary share	$ (0.84)	$ 8.68	$ (1.84)	$ 7.82
Earnings per ordinary share - diluted
Diluted net (loss) / income per ordinary share	$ (0.84)	$ 8.51	$ (1.84)	$ 7.67
Weighted average shares - basic	46,668,554	46,037,900	46,634,026	45,754,766
Weighted average shares - diluted	46,668,554	46,929,870	46,634,026	46,678,835
License revenues
Total revenues		$ 462,400		$ 462,400
Collaboration revenues
Total revenues	$ 497	$ 1,468	$ 2,289	$ 1,922