CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Current assets
Cash and cash equivalents	$ 500,524	$ 556,256
Accounts receivable and contract asset	3,119	58,768
Inventories	2,949
Prepaid expenses	15,126	10,540
Other current assets and receivables	1,581	2,675
Total current assets	523,299	628,239
Non-current assets
Property, plant and equipment, net of accumulated depreciation of $39.4 million as of June 30, 2022 and $36.9 million as of December 31, 2021	45,984	43,505
Operating lease right-of-use assets	28,482	25,573
Intangible assets, net, including an in-process research and development asset of $56.0 million as of June 30, 2022 and $60.8 million as of December 31, 2021	57,450	62,686
Goodwill	24,976	27,633
Deferred tax assets, net	15,046	15,647
Other non-current assets	5,974	5,897
Total non-current assets	177,912	180,941
Total assets	701,211	809,180
Current liabilities
Accounts payable	10,028	2,502
Accrued expenses and other current liabilities	23,047	28,487
Current portion of contingent consideration	8,681
Current portion of operating lease liabilities	6,505	5,774
Total current liabilities	48,261	36,763
Non-current liabilities
Long-term debt	101,890	100,963
Contingent consideration, net of current portion	20,405	29,542
Operating lease liabilities, net of current portion	30,721	28,987
Deferred tax liability, net	9,953	12,913
Other non-current liabilities	3,493	4,236
Total non-current liabilities	166,462	176,641
Total liabilities	214,723	213,404
Commitments and contingencies
Shareholders' equity
Ordinary shares, 0.05 par value: 80,000,000 shares authorized as of June 30, 2022 and December 31, 2021 and 46,684,583 and 46,298,635 ordinary shares issued and outstanding as of June 30, 2022 and December 31, 2021, respectively	2,823	2,802
Additional paid-in-capital	1,092,176	1,076,972
Accumulated other comprehensive loss	(67,630)	(28,856)
Accumulated deficit	(540,881)	(455,142)
Total shareholders' equity	486,488	595,776
Total liabilities and shareholders' equity	$ 701,211	$ 809,180