CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Total revenues	$ 104	$ 1,136
Operating expenses:
Research and development expenses	(26,013)	(20,537)
Selling, general and administrative expenses	(9,072)	(8,067)
Total operating expenses	(35,085)	(28,604)
Other income	857	313
Other expense	(339)	(349)
Loss from operations	(34,463)	(27,504)
Interest income	822	442
Interest expense	(975)	(957)
Foreign currency (losses) / gains, net	4,602	2,274
Other non-operating (losses) / gains, net	2,015	(2,027)
Net loss	(27,999)	(27,772)
Other comprehensive (loss) / income:
Foreign currency translation adjustments net of tax impact of nil for the year ended December 31, 2019 (2018: $(0.2) million and 2017: $0.2 million)	(5,277)	2,468
Total comprehensive loss	$ (33,276)	$ (25,304)
Basic and diluted net loss per ordinary share	$ (0.63)	$ (0.74)
Weighted average shares used in computing basic and diluted net loss per ordinary share	44,279,456	37,676,172
License revenues from related party
Total revenues	$ 47	$ 557
Collaboration revenues from related party
Total revenues	$ 57	$ 579