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Share-based compensation - Summary of share-based compensation expense and unrecognized costs (Details) - 2014 Plan - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019	Dec. 31, 2019	Jun. 30, 2018
Share-based compensation
Authorized shares			3,000,000	8,601,471
Share-based compensation expense	$ 4,340	$ 4,278
Unrecognized compensation costs	$ 49,904
Weighted-average remaining period for recognition (in years)	2 years 8 months 23 days
Research and development expenses
Share-based compensation
Share-based compensation expense	$ 2,382	1,980
Selling, general and administrative expense
Share-based compensation
Share-based compensation expense	1,958	2,298
Share options
Share-based compensation
Share-based compensation expense	$ 2,208	2,076
Outstanding of fully vested share options	3,003,430		2,683,104
Unrecognized compensation costs	$ 28,880
Weighted-average remaining period for recognition (in years)	3 years 1 month 6 days
Restricted share units ("RSUs")
Share-based compensation
Share-based compensation expense	$ 1,444	930
Unrecognized compensation costs	$ 16,746
Weighted-average remaining period for recognition (in years)	2 years 4 months 24 days
Performance share units ("PSUs")
Share-based compensation
Share-based compensation expense	$ 688	$ 1,272
Unrecognized compensation costs	$ 4,278
Weighted-average remaining period for recognition (in years)	1 year 6 months 29 days