CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended
Mar. 31, 2019	Mar. 31, 2018
Total	$ 1,136	$ 3,478
Operating expenses:
Research and development expenses	(20,537)	(17,058)
Selling, general and administrative expenses	(8,067)	(6,301)
Total operating expenses	(28,604)	(23,359)
Other income	313	615
Other expense	(349)	(333)
Loss from operations	(27,504)	(19,599)
Interest income	442	253
Interest expense	(957)	(416)
Foreign currency gains / (losses), net	2,274	178
Other non-operating (loss) / income, net	(2,027)	703
Loss before income tax expense	(27,772)	(18,881)
Income tax benefit / (expense)		92
Net loss	(27,772)	(18,789)
Other comprehensive (loss) / income, net of income tax:
Foreign currency translation adjustments net of tax impact of $(0.2) million for the year ended December 31, 2018 (2017: $0.2 million and 2016: $(1.1) million)	2,468	(179)
Total comprehensive loss	$ (25,304)	$ (18,968)
Basic and diluted net loss per ordinary share	$ (740.00)	$ (590.00)
Weighted average shares used in computing basic and diluted net loss per ordinary share	37,676,172	31,710,497
License revenues from related party
Total	$ 557	$ 2,451
Collaboration revenues from related party
Total	$ 579	$ 1,027

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