CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Current assets
Cash and cash equivalents	$ 208,787	$ 234,898
Accounts receivable and accrued income from related party	461	233
Prepaid expenses	3,597	1,116
Other current assets	350	329
Total current assets	213,195	236,576
Non-current assets
Property, plant and equipment, net	27,778	29,179
Operating lease right-of-use asset	18,678
Intangible assets, net	5,917	5,201
Goodwill	496	506
Restricted cash	2,930	2,444
Total non-current assets	55,799	37,330
Total assets	268,994	273,906
Current
Accounts payable	3,527	3,792
Accrued expenses and other current liabilities	7,311	8,232
Current portion of operating lease liability	3,808
Current portion of deferred rent		311
Current portion of deferred revenue	7,772	7,634
Total current liabilities	22,418	19,969
Non-current
Long-term debt, net of current portion	35,630	35,471
Operating lease liability, net of current portion	23,344
Deferred rent, net of current portion		8,761
Deferred revenue, net of current portion	27,465	28,861
Derivative financial instruments related party	2,603	803
Other non-current liabilities	422	435
Total non-current liabilities	89,464	74,331
Total liabilities	111,882	94,300
Commitments and contingencies (see note 5)
Shareholders' equity
Ordinary shares, €0.05 par value: 60,000,000 shares authorized at March 31, 2019 and December 31, 2018 and 37,763,842 and 37,351,653 ordinary shares issued and outstanding at March 31, 2019 and December 31, 2018, respectively.	2,322	2,299
Additional paid-in-capital	727,795	720,072
Accumulated other comprehensive loss	(9,727)	(7,259)
Accumulated deficit	(563,278)	(535,506)
Total shareholders' equity	157,112	179,606
Total liabilities and shareholders' equity	$ 268,994	$ 273,906