CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended	9 Months Ended
Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Total revenues	$ 3,148	$ 2,260	$ 9,676	$ 10,523
Operating expenses:
Research and development expenses	(20,541)	(20,103)	(56,092)	(53,963)
Selling, general and administrative expenses	(5,898)	(5,584)	(18,095)	(17,352)
Total operating expenses	(26,439)	(25,687)	(74,187)	(71,315)
Other income	557	14,413	1,737	14,995
Other expense	(490)	(261)	(1,252)	(2,901)
Loss from operations	(23,224)	(9,275)	(64,026)	(48,698)
Interest income	949	10	1,785	33
Interest expense	(515)	(577)	(1,496)	(1,583)
Foreign currency gains / (losses), net	455	(681)	2,888	(1,845)
Other non-operating (loss) / income, net	268		(330)	29
Loss before income tax expense	(22,067)	(10,523)	(61,179)	(52,064)
Income tax benefit / (expense)	32	278	(237)	278
Net loss	(22,035)	(10,245)	(61,416)	(51,786)
Other comprehensive (loss) / income, net of income tax:
Foreign currency translation adjustments net of tax impact of $0.0 million and $0.3 million for the three months ended September 30, 2018 and 2017, respectively, and $(0.2) million and $0.3 million for the nine months ended September 30, 2018 and 2017, respectively.	(799)	22	(3,491)	748
Total comprehensive loss	$ (22,834)	$ (10,223)	$ (64,907)	$ (51,038)
Basic and diluted net loss per ordinary share	$ (0.59)	$ (0.40)	$ (1.75)	$ (2.03)
Weighted average shares used in computing basic and diluted net loss per ordinary share	37,247,193	25,632,642	35,074,531	25,546,225
License revenues
Total revenues				$ 8
License revenues from related party
Total revenues	$ 2,518	$ 1,124	$ 7,092	3,060
Collaborative revenues
Total revenues				4,638
Collaborative revenues from related party
Total revenues	$ 630	$ 1,136	$ 2,584	$ 2,817

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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