CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2018	Dec. 31, 2017
Current assets
Cash and cash equivalents	$ 239,546	$ 159,371
Accounts receivable and accrued income from related party	552	1,586
Prepaid expenses	1,670	1,139
Other current assets	312	687
Total current assets	242,080	162,783
Non-current assets
Property, plant and equipment, net	30,802	34,281
Intangible assets, net	5,211	9,570
Goodwill	513	530
Restricted cash	2,454	2,480
Total non-current assets	38,980	46,861
Total assets	281,060	209,644
Current liabilities
Accounts payable	4,115	2,908
Accrued expenses and other current liabilities	7,098	8,838
Current portion of long-term debt	11,111	1,050
Current portion of deferred rent	1,093	737
Current portion of deferred revenue	8,594	4,613
Current portion of contingent consideration		1,084
Total current liabilities	32,011	19,230
Non-current liabilities
Long-term debt, net of current portion	9,597	19,741
Deferred rent, net of current portion	8,156	9,114
Deferred revenue, net of current portion	29,849	67,408
Contingent consideration, net of current portion		2,880
Derivative financial instruments related party	1,085	1,298
Other non-current liabilities	510	614
Total non-current liabilities	49,197	101,055
Total liabilities	81,208	120,285
Commitments and contingencies (see note 13)
Shareholders' equity
Ordinary shares, €0.05 par value: 60,000,000 shares authorized at September 30, 2018 and December 31, 2017 and 37,275,199 and 31,339,040 ordinary shares issued and outstanding at September 30, 2018 and December 31, 2017, respectively.	2,294	1,947
Additional paid-in-capital	716,663	566,530
Accumulated other comprehensive loss	(5,487)	(3,800)
Accumulated deficit	(513,618)	(475,318)
Total shareholders' equity	199,852	89,359
Total liabilities and shareholders' equity	$ 281,060	$ 209,644