CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Cash flows from operating activities
Net loss	$ (18,789)	$ (20,272)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,550	1,794
Share-based compensation expense	2,527	1,605
Change in fair value of derivative financial instruments and contingent consideration	(756)	105
Unrealized foreign exchange (gains) / losses	(131)	176
Change in deferred taxes	(92)
Change in lease incentives	(72)	1,305
Changes in operating assets and liabilities:
Accounts receivable and accrued income, prepaid expenses and other current assets	(1,142)	8,154
Accounts payable	681	(683)
Accrued expenses and other liabilities	(2,656)	(2,584)
Deferred revenue	(2,560)	(1,268)
Net cash used in operating activities	(21,440)	(11,668)
Cash flows from investing activities
Purchase of property, plant and equipment	(648)	(1,969)
Net cash used in investing activities	(648)	(1,969)
Cash flows from financing activities
Proceeds from issuance of shares related to employee stock option plans	1,562	441
Net cash generated from financing activities	1,562	441
Currency effect cash, cash equivalents and restricted cash	1,997	980
Net decrease in cash, cash equivalents and restricted cash	(18,529)	(12,216)
Cash, cash equivalents and restricted cash at beginning of period	161,851	134,324
Cash, cash equivalents and restricted cash at the end of period	143,322	122,108
Supplemental cash flow disclosures:
Total cash, cash equivalents and restricted cash	161,851	134,324
Cash paid for interest	(409)	(413)
Non-cash decreases in accounts payables related to purchases of intangible assets and property, plant and equipment	$ 26	$ (949)