CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended
Mar. 31, 2018	Mar. 31, 2017
Total revenues	$ 3,478	$ 3,321
Operating expenses:
Research and development expenses	(17,058)	(16,994)
Selling, general and administrative expenses	(6,301)	(6,358)
Total operating expenses	(23,359)	(23,352)
Other income	615	316
Other expense	(333)
Loss from operations	(19,599)	(19,715)
Interest income	253	11
Interest expense	(416)	(504)
Foreign currency gains / (losses), net	178	(93)
Other non-operating income, net	703	29
Loss before income tax expense	(18,881)	(20,272)
Income tax benefit / (expense)	92
Net loss	(18,789)	(20,272)
Other comprehensive income / (loss), net of income tax:
Foreign currency translation adjustments net of tax impact of $0.1 million for the three months ended March 31, 2018 (three months ended March 31, 2017: nil)	(179)	322
Total comprehensive loss	$ (18,968)	$ (19,950)
Basic and diluted net loss per ordinary share	$ (0.59)	$ (0.80)
Weighted average shares used in computing basic and diluted net loss per ordinary share	31,710,497	25,443,609
License revenues
Total revenues		$ 234
License revenues from related party
Total revenues	$ 2,451	949
Collaborative revenues
Total revenues		1,580
Collaborative revenues from related party
Total revenues	$ 1,027	$ 558

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Generally recurring costs associated with normal operations except for the portion of these expenses which can be clearly related to production and included in cost of sales or services. Includes selling, general and administrative expense.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS).

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