Property, plant and equipment (Tables)

3 Months Ended

Mar. 31, 2018

Property, plant and equipment

Schedule of property, plant and equipment

	March 31,		December 31,
	2018		2017
	in thousands
Leasehold improvements	$	33,185	$	32,297
Laboratory equipment		15,989		15,976
Office equipment		2,359		2,304
Construction-in-progress		653		745
Total property, plant, and equipment		52,186		51,322
Less accumulated depreciation		(18,347)		(17,041)
Property, plant and equipment, net	$	33,839	$	34,281