CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS
License revenues	$ (226)	$ 250	$ 8	$ 491
License revenues from related party	987	1,006	1,936	1,984
Collaboration revenues	3,058	1,558	4,638	2,984
Collaboration revenues from related party	1,123	1,637	1,681	3,287
Total revenues	4,942	4,451	8,263	8,746
Operating expenses:
Research and development expenses	(16,866)	(19,221)	(33,860)	(35,927)
Selling, general and administrative expenses	(5,410)	(7,834)	(11,768)	(15,132)
Total operating expenses	(22,276)	(27,055)	(45,628)	(51,059)
Other income	266	475	582	920
Other expense	(2,640)		(2,640)
Loss from operations	(19,708)	(22,129)	(39,423)	(41,393)
Interest income	12	15	23	37
Interest expense	(502)	(549)	(1,006)	(1,178)
Foreign currency gains / (losses), net	(1,071)	920	(1,164)	(1,268)
Other non-operating income, net		330	29	647
Loss before income tax expense	(21,269)	(21,413)	(41,541)	(43,155)
Income tax benefit / (expense)		333		(224)
Net loss	(21,269)	(21,080)	(41,541)	(43,379)
Other comprehensive loss, net of income tax:
Foreign currency translation adjustments net of tax impact of nil and $0.3 million for the three months ended June 30, 2017 and 2016, respectively, and nil and (0.2) million for the six months ended June 30, 2017 and 2016, respectively.	404	(4,101)	726	579
Total comprehensive loss	$ (20,865)	$ (25,181)	$ (40,815)	$ (42,800)
Basic and diluted net loss per common share (in dollars per share)	$ (0.83)	$ (0.84)	$ (1.63)	$ (1.74)
Weighted average shares used in computing basic and diluted net loss per common share (in shares)	25,560,348	25,077,350	25,502,301	24,886,996