X0306 4 2020-01-15 0001590560 uniQure N.V. QURE 0001696698 Kuta Alexander Edward III C/O UNIQURE N.V. PAASHEUVELWEG 25A AMSTERDAM P7 11058BP NETHERLANDS 0 1 0 0 Executive VP, Operations Ordinary Shares 2020-01-15 4 M 0 4000 5.31 A 45578 D Ordinary Shares 2020-01-15 4 S 0 4000 68.97 D 41578 D Stock Option (Right to Buy) 5.31 2020-01-15 4 M 0 4000 0 D 2027-01-23 Ordinary Shares 4000 98000 D The Stock Option vested 25% on January 23, 2018 (the first anniversary of the date of grant), and vests 6.25% quarterly thereafter until fully vested, subject to the Reporting Person's continued relationship with the Issuer through such dates. The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $68.61 to $69.35. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Christian Klemt, Attorney-in-Fact 2020-01-16