<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2018-04-23</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001590560</issuerCik>
        <issuerName>uniQure N.V.</issuerName>
        <issuerTradingSymbol>QURE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001740338</rptOwnerCik>
            <rptOwnerName>ForUniqure B.V.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O FORBION CAPITAL PARTNERS</rptOwnerStreet1>
            <rptOwnerStreet2>GOOIMEER 2-35</rptOwnerStreet2>
            <rptOwnerCity>1411 DC NAARDEN</rptOwnerCity>
            <rptOwnerState>P7</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>NETHERLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001634152</rptOwnerCik>
            <rptOwnerName>Forbion 1 Management B.V.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O FORBION CAPITAL PARTNERS</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>1411 DC NAARDEN</rptOwnerCity>
            <rptOwnerState>P7</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>NETHERLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>4376883</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">ForUniQure B.V. (&quot;ForUniQure&quot;) acquired these shares as part of an internal restructuring by Forbion Capital Partners, and the shares are held directly by ForUniQure. Forbion 1 Management B.V. (&quot;Forbion Management &quot;) is the director of ForUniQure and may be deemed to have voting, investment and dispositive power with respect to the shares held by ForUniQure. Forbion Management disclaims Section 16 beneficial ownership of the shares held by ForUniQure, except to the extent, if any, of its pecuniary interest therein.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>FORUNIQURE B.V., By:  Forbion 1 Management B.V., its director, By:  Martien van Osch, its director, /a/ Martien van Osch, By:  H.A. Slootweg, its director, /s/ H.A. Slootweg</signatureName>
        <signatureDate>2018-05-16</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>FORBION 1 MANAGEMENT B.V., By:  Martien van Osch, its director, /s/ Martien van Osch, By:  H.A. Slootweg, its director, /s/ H.A. Slootweg</signatureName>
        <signatureDate>2018-05-16</signatureDate>
    </ownerSignature>
</ownershipDocument>
