144 0001589725 XXXXXXXX LIVE 0000882796 BioCryst Pharmaceuticals Inc 000-23186 4505 Emperor Blvd Suite 200 Durham NC 27703 9198591302 Helen Thackray Officer Common Merrill Lynch

1800 K ST NW Suite 800 Washington DC 20006

43275 307685 210543224 11/21/2025 NASDAQ Common 03/31/2022 Stock Plan Activity Issuer N 17400 03/31/2022 n/a Common 12/14/2022 Stock Plan Activity Issuer N 7875 12/14/2022 n/a Common 03/31/2023 Stock Plan Activity Issuer N 18000 03/31/2023 n/a Y 11/21/2025 Helen Thackray