SECOND AMENDMENT TO
LOAN AND SECURITY AGREEMENT

This Second Amendment to Loan and Security Agreement is entered into as of August 6, 2025 (the “Amendment”) is entered into between CANADIAN IMPERIAL BANK OF COMMERCE (“Bank”) and PROCEPT BIOROBOTICS CORPORATION, a Delaware corporation (“Borrower Representative”).

RECITALS

A.Borrower and Bank are parties to that certain Loan and Security Agreement, dated as of October 6, 2022, (as amended by that certain First Amendment to Loan and Security Agreement, dated as of June 1, 2023, and as further amended from time to time, the “Agreement”).

B.The parties desire to amend the terms of the Agreement as set forth in this Amendment.

AGREEMENT

NOW, THEREFORE, the parties agree as follows:

1.Definitions. Capitalized terms used but not defined in this Amendment shall have the respective meanings given to them in the Agreement.

2.Amendments.

2.1Exhibit A of the Agreement is hereby amended by adding or amending and restating the following terms in appropriate alphabetical order:

“Permitted Foreign Accounts” means each Collateral Account owned by a Loan Party and maintained at a bank located outside of the United States and Canada, provided that the aggregate amount held in all such accounts shall not exceed $5,000,000.

“Run-Rate Revenue” means, as of any date of determination, the product of (a) Revenue of Borrower Representative measured on a trailing three (3) month basis, as determined by Bank based on financial materials delivered to Bank, multiplied by (b) four (4).

“Second Amendment Effective Date” means August 6, 2025.

2.2Exhibit A of the Agreement is hereby amended by deleting the definition of “Amortization Date”.

2.3Section 2.3(b) of the Agreement is amended to read as follows:

(b)    Repayment. Borrowers shall make consecutive monthly payments of only accrued and unpaid interest in accordance with Section 2.5. Any and all unpaid Obligations, including outstanding principal and any accrued and unpaid interest in respect of the Term Loan, other fees and other sums, if any, shall be due and payable in full on the Term Loan Maturity Date. The Term Loan may only be prepaid in accordance with Sections 2.3(c) and 2.3(d).

2.4Section 6.2(i) of the Agreement is amended to read as follows:

(i)    Intellectual Property Report. A prompt report in form reasonably acceptable to Bank, listing any newly filed applications or registrations that any Loan Party or any of its Subsidiaries has made or filed in respect of any Patents, Copyrights or Trademarks since the date

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of the last report, as well as any material change in any Loan Party or any of its Subsidiaries’ Intellectual Property, such that Bank may perfect its security interests in all such Intellectual Property.

2.5Section 6.6(b) of the Agreement is amended to read as follows:

(b)    Borrower Representative and its Subsidiaries shall maintain in Collateral Accounts with Bank (including accounts with Bank’s corporate and institutional services group which, for the avoidance of doubt, may invest in non-Bank affiliated Cash Equivalents) cash and Cash Equivalents in an amount not less than (a) if cash and Cash Equivalents of Borrower Representative and its Subsidiaries is less than $50,000,000, 100% of the aggregate amount of cash and Cash Equivalents of Borrower Representative and its Subsidiaries on a consolidated basis held on Bank’s balance sheet or (b) if cash and Cash Equivalents of Borrower Representative and its Subsidiaries is greater than or equal to $50,000,000, the greater of (i) $50,000,000 or (ii) 50% of such cash and Cash Equivalents of Borrower Representative and its Subsidiaries, with a minimum of $50,000,000 held on Bank’s balance sheet, provided that amounts in excess of $50,000,000 may be held outside of Bank in Collateral Accounts managed by CIBC. All Collateral Accounts of Borrowers and Guarantors shall be subject to an Account Control Agreement or first priority security interest by “control” or foreign equivalent thereof in favor of Bank. Borrower Representative and its Subsidiaries shall comply with the requirements in this Section 6.6(b) no later than sixty (60) days after the Second Amendment Effective Date.

2.6Section 6.12(b) of the Agreement is amended to read as follows:

(b)    With respect to any property or assets of a Loan Party located with a third party, including a bailee, datacenter or warehouse (other than Excluded Locations) for all such third party locations holding property or assets in an amount equal to or greater than $10,000,000 in the aggregate, the Loan Parties shall cause each such third party to execute and deliver a Collateral Access Agreement for such location, including an acknowledgment from each of the third parties that it is holding or will hold such property for Bank’s benefit. Loan Parties shall deliver to Bank each warehouse receipt, where negotiable, covering any such property.

3.Limitation of Amendments. The Amendments set forth in Section 2 above, are effective for the purposes set forth herein and shall be limited precisely as written and shall not be deemed to (a) be a consent to any amendment, waiver or modification of any other term or condition of any Loan Document, or (b) otherwise prejudice any right or remedy which Bank may now have or may have in the future under or in connection with any Loan Document. Except as modified by this Amendment, the Loan Documents remain in full force and effect and are hereby reaffirmed.

4.Obligations. The Loan Parties hereby acknowledge that the Obligations are due and owing as set forth in the Agreement to Bank without setoff, recoupment, defense or counterclaim, in law or in equity, of any nature or kind. All guarantees and security interests granted to Bank under any Loan Document are hereby reaffirmed by each Loan Party and shall continue without novation. Except as expressly set forth herein, the terms of the Loan Documents remain in effect. This Amendment is a Loan Document.

5.Representations. To induce Bank to enter into this Amendment, each Loan Party represents and warrants as follows:

5.1The representations and warranties contained in the Agreement and the other Loan Documents, are true and correct in all material respects as of the date of this Amendment (except for such representations and warranties referring to another date, which representations and warranties are true and correct in all material respects as of such date).

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5.2No Event of Default has occurred and is continuing.

5.3Each Loan Party has the power and authority to execute and deliver this Amendment and to perform its obligations under the Agreement, as amended by this Amendment.

5.4The execution and delivery by each Loan Party of this Amendment and the performance by each Loan Party of the obligations under the Loan Documents as amended by this Amendment, (a) have been duly authorized by all necessary action on the part of the applicable Loan Party, and (b) (i) will not conflict with the organizational documents of such Loan Party, (ii) will not contravene, conflict with or violate any material Requirement of Law, (iii) will not contravene, conflict with or violate any applicable order, writ, judgment, injunction, determination or award of any Governmental Authority by which a Loan Party or any of its Subsidiaries or their property or assets may be bound or affected, (iv) will not require any action by, filing, registration, or qualification or Governmental Approval from, any Governmental Authority (except such governmental approvals which have already been obtained and are in full force and effect), or (v) will not conflict with, contravene, or constitute a default under or result in or permit the termination or acceleration of any agreement by which any Loan Party is bound, in each case except as could not reasonably be expected to result in a Material Adverse Effect.

5.5This Amendment has been duly executed and delivered by the Loan Parties party thereto, and constitutes the valid and binding obligation of the Loan Parties party thereto, enforceable against such Loan Party in accordance with its terms, except as such enforceability may be limited by bankruptcy, insolvency, reorganization, liquidation, moratorium or other similar laws of general application and equitable principles relating to or affecting creditors’ rights.

6.Conditions. As a condition to the effectiveness of this Amendment, Bank shall have received the following:

(a)this Amendment, duly executed by the Loan Parties and Bank;

(b)receipt of all documentation and other information required by Bank with respect to the Borrower Representative under applicable “know-your-customer” and anti-money laundering rules and regulations;

(c)evidence satisfactory to Bank that Borrower Representative maintains no less than $275,000,000 in Unrestricted Cash and Cash Equivalents in Deposit Accounts which are demand deposit accounts or money market deposit accounts held at CIBC or subject to an Account Control Agreement in favor of CIBC as of the date hereof;

(d)evidence satisfactory to Bank of Borrower’s achievement of Run-Rate Revenue greater than or equal to $285,000,000 as of the date hereof; and

(e)all reasonable and documented Bank Expenses incurred in connection with this Amendment.

7.Counterparts; Electronic Execution of Documents. This Amendment may be executed in any number of counterparts and by different parties on separate counterparts, each of which, when executed and delivered, is an original, and all taken together, constitute one Agreement. The words “execution,” “signed,” “signature” and words of like import herein shall be deemed to include electronic signatures or the keeping of records in electronic form, each of which shall be of the same legal effect, validity and enforceability as a manually executed signature or the use of a paper-based recordkeeping system, as the case may be, to the extent and as provided for in any applicable law, including, without limitation, any state law based on the Uniform Electronic Transactions Act. Delivery of an executed counterpart of a signature page of this Amendment or any document delivered in connection therewith by electronic means, including by email delivery of a “.pdf” format data file, shall be effective as delivery of an original executed counterpart thereof.

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8.Choice of Law, Venue and Jury Trial Waivers. The provisions of Section 11 of the Agreement are hereby incorporated into this Amendment as if fully set forth herein, mutatis mutandis.

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

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[SIGNATURE PAGE TO SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT]

IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed as of the first date above written.

BORROWER REPRESENTATIVE:

PROCEPT BIOROBOTICS CORPORATION

By: /s/ Kevin Waters

Name: Kevin Waters

Title: EVP, Chief Financial Officer

BANK:

CANADIAN IMPERIAL BANK OF COMMERCE

By: /s/ Joseph C. Hammer

Name: Joseph C. Hammer

Title: Assistant General Manager

By: /s/ Sarah Perkins

Name: Sarah Perkins

Title: Assistant General Manager

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