<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:0d5eb001-dd58-4273-b170-1aabbc55a731,g:fe834c59-5a1a-4f20-bf33-0bab52d539f7-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.zosanopharma.com/role/CoverPage" xlink:type="simple" xlink:href="zsan-20220105.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.zosanopharma.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_813cede1-3b90-4b01-8fac-024e05ecf7b0" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_DocumentType_813cede1-3b90-4b01-8fac-024e05ecf7b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_24dd7523-b582-4afd-a790-dc1df4dc5ed4" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_DocumentPeriodEndDate_24dd7523-b582-4afd-a790-dc1df4dc5ed4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_421ed9a6-1db4-4718-be3d-de634b8b1bc4" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_EntityRegistrantName_421ed9a6-1db4-4718-be3d-de634b8b1bc4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_b24d0d21-7a3f-44e7-9e42-d44e7fbc7c29" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_EntityIncorporationStateCountryCode_b24d0d21-7a3f-44e7-9e42-d44e7fbc7c29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_c528b153-993b-4ca3-8a70-b000c6c68aba" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_EntityFileNumber_c528b153-993b-4ca3-8a70-b000c6c68aba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_778db557-7ca6-490e-af70-11acdf99e2da" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_EntityTaxIdentificationNumber_778db557-7ca6-490e-af70-11acdf99e2da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_ea2e9be8-420b-4b6f-b6a2-1aada77e32e6" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_EntityAddressAddressLine1_ea2e9be8-420b-4b6f-b6a2-1aada77e32e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_ff77b938-a1ca-4385-83fc-014f61624afd" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_EntityAddressCityOrTown_ff77b938-a1ca-4385-83fc-014f61624afd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_adaf8b26-5498-4334-a7fb-ad5c4d355405" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_EntityAddressStateOrProvince_adaf8b26-5498-4334-a7fb-ad5c4d355405" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_d1b36fb2-fe87-4745-b5b4-7ee53a31db5e" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_EntityAddressPostalZipCode_d1b36fb2-fe87-4745-b5b4-7ee53a31db5e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_b765a382-ec00-41d6-a663-606cc3bd123e" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_CityAreaCode_b765a382-ec00-41d6-a663-606cc3bd123e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_9139a53f-49a9-4ac3-bf60-e898b18b26fd" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_LocalPhoneNumber_9139a53f-49a9-4ac3-bf60-e898b18b26fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_0e47da85-1a14-455b-8c34-4e1719aa0330" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_WrittenCommunications_0e47da85-1a14-455b-8c34-4e1719aa0330" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_bcfa35ba-59fb-4c34-8062-7179f77a4062" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_SolicitingMaterial_bcfa35ba-59fb-4c34-8062-7179f77a4062" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_cc6062e1-7332-4593-a48b-681dcd161090" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_PreCommencementTenderOffer_cc6062e1-7332-4593-a48b-681dcd161090" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_ad073189-7f15-4790-a6c1-a7da92938414" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_ad073189-7f15-4790-a6c1-a7da92938414" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_1d98afc0-85cc-4114-ad99-f0b76b35a4c1" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_Security12bTitle_1d98afc0-85cc-4114-ad99-f0b76b35a4c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_7f7ddf1b-b7fa-4f1b-8444-99db684d1a00" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_TradingSymbol_7f7ddf1b-b7fa-4f1b-8444-99db684d1a00" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_4d4e6994-a91d-4ab1-ab4a-0ecebf46969f" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_SecurityExchangeName_4d4e6994-a91d-4ab1-ab4a-0ecebf46969f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_f8330fe5-be6f-47e7-918b-fb473d067ec0" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_EntityEmergingGrowthCompany_f8330fe5-be6f-47e7-918b-fb473d067ec0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_908103f2-9201-431c-b907-39fa9622868e" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_AmendmentFlag_908103f2-9201-431c-b907-39fa9622868e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_356dffd5-e5c6-43ad-83f7-ed8cce675a00" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_84f4cabd-c018-4229-b6c1-d1935629dc11" xlink:to="loc_dei_EntityCentralIndexKey_356dffd5-e5c6-43ad-83f7-ed8cce675a00" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
