<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2019-06-18</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0001586105</issuerCik>
        <issuerName>Zyla Life Sciences</issuerName>
        <issuerTradingSymbol>ZCOR</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001698044</rptOwnerCik>
            <rptOwnerName>Duster Luke</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CR GROUP L.P., 1000 MAIN ST.</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 2500</rptOwnerStreet2>
            <rptOwnerCity>HOUSTON</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>77002</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <footnotes></footnotes>

    <remarks>Effective as of June 18, 2019, Luke Duster resigned from his position as a director of Zyla Life Sciences. As a result, Luke Duster is no longer subject to Section 16 of the Securities Exchange Act of 1934 in connection with his transactions in the equity securities of Zyla Life Sciences and therefore will no longer report any such transactions on Form 4 or Form 5.</remarks>

    <ownerSignature>
        <signatureName>/s/ Luke Duster</signatureName>
        <signatureDate>2019-06-21</signatureDate>
    </ownerSignature>
</ownershipDocument>
