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Note 19 - Discontinued Operations (Details Textual) - USD ($)
3 Months Ended 12 Months Ended
Nov. 06, 2018
Sep. 25, 2018
Dec. 31, 2019
Sep. 30, 2019
Dec. 31, 2019
Dec. 31, 2018
Discontinued Operation, Gain (Loss) from Disposal of Discontinued Operation, before Income Tax, Total         $ 145,982,000
Income (Loss) from Discontinued Operations, Net of Tax, Including Portion Attributable to Noncontrolling Interest, Total       $ (469,000) (469,000) 108,274,000
MidCap Agreement [Member] | MidCap Financial [Member]            
Extinguishment of Debt, Amount   $ 32,300,000        
Debt Instrument, Prepayment and Exit Fees $ 2,300,000 2,300,000        
Laboratory Services Business [Member]            
Proceeds from Divestiture of Businesses   170,000,000        
Disposal Group, Including Discontinued Operation, Consideration   $ 27,900,000        
Discontinued Operation, Gain (Loss) from Disposal of Discontinued Operation, before Income Tax, Total           146,000,000
Discontinued Operation, Intra-Entity Amounts, Discontinued Operation after Disposal, Revenue           8,000,000
Escrow Received from Disposal Group, Including Discontinued Operation     $ 4,100,000      
Escrow Receivable from Disposal Group, Including Discontinued Operation     $ 4,500,000   $ 4,500,000  
Laboratory Services Business [Member] | General and Administrative Expense [Member]            
Professional Fees           $ 3,300,000