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Note 14 - Income Taxes (Tables)
12 Months Ended
Dec. 31, 2019
Notes Tables  
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
(in thousands)
 
2019
   
2018
 
Domestic (United Kingdom)
  $
(8,368
)   $
12,623
 
Foreign (United States)
   
4,611
     
(37,404
)
Loss from continuing operations before income taxes
  $
(3,757
)   $
(24,781
)
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
(in thousands)
 
2019
   
2018
 
Current:
               
Federal
  $
    $
 
U.K.
   
1,401
     
(532
)
Japan
   
(78
)    
(45
)
China
   
(46
)    
(13
)
State
   
(119
)    
 
Total current provision
   
1,158
     
(590
)
Deferred:
               
Federal
   
1,515
     
30,665
 
U.K.
   
(896
)    
(1,343
)
Japan    
85
     
 
State
   
555
     
8,554
 
Total deferred benefit
   
1,259
     
37,876
 
Income tax benefit from continuing operations
  $
2,417
    $
37,286
 
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
   
2019
   
2018
 
Income tax rate
   
19.0
%    
19.0
%
U.K. research and development credit
   
16.2
     
1.8
 
Permanent items
   
(6.1
)    
1.0
 
Prior period adjustments
   
5.9
     
(5.2
)
State taxes
   
(19.0
)    
9.2
 
Other
   
(0.4
)    
2.0
 
Effect of foreign tax rate differential
   
(3.4
)    
2.9
 
Uncertain tax positions
   
2.5
     
(1.7
)
Valuation allowance
   
49.6
     
121.5
 
Effective income tax rate
   
64.3
%    
150.5
%
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
(in thousands)
 
2019
   
2018
 
                 
Deferred tax assets:
               
U.S. federal net operating losses
  $
11,410
    $
11,478
 
State net operating losses (net of federal)
   
2,234
     
2,865
 
U.S. federal research and development credits
   
948
     
849
 
U.K. net operating losses
   
1,132
     
496
 
Share options
   
1,742
     
1,724
 
Accrued liabilities
   
406
     
1,052
 
Operating lease liabilities    
101
     
 
State credits
   
536
     
512
 
Other
   
99
     
136
 
Total deferred tax assets
   
18,608
     
19,112
 
Valuation allowance
   
(16,127
)    
(17,991
)
Total deferred tax assets
  $
2,481
    $
1,121
 
                 
Deferred tax liabilities:
               
Intangibles
  $
(24
)   $
 
Operating lease right-of-use assets    
(113
)    
 
Depreciation    
(118
)    
 
Other assets
   
(63
)    
(69
)
Total deferred tax liabilities
  $
(318
)   $
(69
)
Summary of Valuation Allowance [Table Text Block]
(in thousands)
 
2019
   
2018
 
Beginning of year (January 1)
  $
17,991
    $
48,098
 
Decrease in valuation allowance
   
(1,864
)    
(30,107
)
End of year (December 31)
  $
16,127
    $
17,991
 
Summary of Income Tax Contingencies [Table Text Block]
Balance at December 31, 2018
  $
372
 
Settlement/decreases related to tax positions taken during prior years
   
(372
)
Increases related to tax positions taken during prior years
   
 
Increases related to tax positions taken during the current year
   
 
Balance at December 31, 2019
  $