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Note 7 - Property and Equipment, Net (Tables)
 12 Months Ended
Dec. 31, 2019
Notes Tables  
Property, Plant and Equipment [Table Text Block]
   
December 31,
  
(in thousands)
  
2019
    
2018
  
Laboratory equipment
   $
3,834
     $
2,951
  
Leasehold improvements
    
5,999
      
5,663
  
Office equipment, furniture and fixtures
    
2,101
      
3,019
  
Software
    
870
      
1,626
  
Construction in progress
    
302
      
—
  
Property and equipment
    
13,106
      
13,259
  
Less accumulated depreciation
    
(6,011
 )    
(6,115
 )
Property and equipment, net
   $
7,095
     $
7,144