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Note 6 - Property and Equipment, Net (Tables)
 12 Months Ended
Dec. 31, 2018
Notes Tables  
Property, Plant and Equipment [Table Text Block]
   
December 31,
  
(in thousands)
  
2018
    
2017
  
Laboratory equipment
   $
2,951
     $
2,493
  
Leasehold improvements
    
5,663
      
2,766
  
Office equipment, furniture and fixtures
    
3,019
      
2,205
  
Software
    
1,626
      
756
  
Construction in progress
    
—
      
94
  
Property and equipment
    
13,259
      
8,314
  
Less accumulated depreciation
    
(6,115
)
    
(5,550
)
Property and equipment, net
   $
7,144
     $
2,764