Note 17 - Acquisition Activity - Fair Value of Identified Assets Acquired (Details) - USD ($)	Dec. 31, 2016	Oct. 12, 2016	Jul. 01, 2016	Dec. 31, 2015	Dec. 31, 2014	Jul. 31, 2014
Goodwill	$ 3,822,000			$ 45,000	$ 50,000
Imugen [Member]
Property and equipment			$ 655,000
Intangible assets			18,900,000
Total assets acquired			19,555,000
Goodwill			2,645,000
Total consideration transferred			22,200,000
Property and equipment			655,000
Imugen [Member] | Technology-Based Intangible Assets [Member]
Intangible assets			5,100,000
Imugen [Member] | Customer Relationships [Member]
Intangible assets			2,700,000
Imugen [Member] | Trademarks and Trade Names [Member]
Intangible assets			1,900,000
Imugen [Member] | In Process Research and Development, Indefinite Lived [Member]
Intangible assets			$ 9,200,000
Immunetics [Member]
Property and equipment		$ 787,000
Intangible assets		8,600,000
Total assets acquired		10,608,000
Goodwill		1,177,000
Total consideration transferred		9,444,000
Cash		285,000
Accounts receivable, net		347,000
Inventory, net		420,000
Prepaid expenses and other assets		199,000
Accounts payable		(319,000)
Accrued liabilities		(739,000)
Other liabilities		(1,283,000)
Total liabilities assumed		(2,341,000)
Net assets acquired		8,267,000
Property and equipment		787,000
Accounts payable		(319,000)
Accrued liabilities		(739,000)
Immunetics [Member] | Technology-Based Intangible Assets [Member]
Intangible assets		860,000
Immunetics [Member] | Customer Relationships [Member]
Intangible assets		400,000
Immunetics [Member] | Trade Names [Member]
Intangible assets		290,000
Immunetics [Member] | Grants [Member]
Intangible assets		50,000
Immunetics [Member] | In Process Research and Development, Indefinite Lived [Member]
Intangible assets		$ 6,970,000
Boulder Diagnostics Inc [Member]
Property and equipment						$ 359,000
Total assets acquired						3,061,000
Goodwill						55,000
Total consideration transferred						2,971,000
Cash						8,000
Accounts receivable, net						15,000
Inventory, net						40,000
Prepaid expenses and other assets						12,000
Accounts payable						(97,000)
Accrued liabilities						(14,000)
Other liabilities						(34,000)
Total liabilities assumed						(145,000)
Net assets acquired						2,916,000
Property and equipment						359,000
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Indefinite-Lived Intangible Assets						2,627,000
Accounts payable						(97,000)
Accrued liabilities						$ (14,000)