Note 6 - Goodwill and Acquired Intangible Assets - Changes in Carrying Amount of Goodwill (Details) - USD ($)	3 Months Ended	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2016	Dec. 31, 2015
Balance		$ 45,000	$ 50,000
Foreign currency adjustment		(2,000)	(5,000)
Balance	$ 3,822,000	3,822,000	$ 45,000
Impairment charge – Boulder goodwill		(43,000)
Imugen [Member]
Imugen acquisition (Note 17)		2,645,000
Impairment charge – Boulder goodwill		0
Immunetics [Member]
Imugen acquisition (Note 17)		$ 1,177,000
Impairment charge – Boulder goodwill	$ 0