Note 6 - Intangible Assets (Details Textual) - USD ($)	3 Months Ended	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Acquired Finite-lived Intangible Assets, Weighted Average Useful Life		13 years
Amortization of Intangible Assets		$ 435,000	$ 92,000	$ 43,000
Finite-Lived Intangible Assets, Amortization Expense, Next Twelve Months	$ 1,000,000	1,000,000
Finite-Lived Intangible Assets, Amortization Expense, Year Three	900,000	900,000
Indefinite-Lived Intangible Assets (Excluding Goodwill)	16,170,000	16,170,000	1,782,000
Finite-Lived Intangible Assets, Amortization Expense, Year Five	900,000	900,000
Finite-Lived Intangible Assets, Amortization Expense, Year Four	900,000	900,000
Finite-Lived Intangible Assets, Amortization Expense, Year Two	900,000	900,000
In Process Research and Development, Indefinite Lived [Member] | Imugen [Member]
Indefinite-Lived Intangible Assets (Excluding Goodwill)	9,200,000	9,200,000
In Process Research and Development, Indefinite Lived [Member] | Immunetics [Member]
Indefinite-Lived Intangible Assets (Excluding Goodwill)	6,970,000	$ 6,970,000
In Process Research and Development, Indefinite Lived [Member] | Boulder Diagnostics Inc [Member]
Indefinite-Lived Intangible Assets (Excluding Goodwill)			$ 1,782,000
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)	$ 1,400,000