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Note 5 - Property and Equipment, Net (Tables)
 12 Months Ended
Dec. 31, 2016
Notes Tables  
Property, Plant and Equipment [Table Text Block]
 
 
December 31,
 
(in thousands)
 
201
6
 
 
201
5
 
Laboratory equipment
   $
5,971
     $
4,865
  
Leasehold improvements
    
3,199
      
2,783
  
Office equipment, furniture and fixtures
    
3,364
      
2,841
  
Software
    
1,479
      
1,172
  
Specialized shipping containers
    
2,655
      
2,177
  
Construction in progress
    
848
      
200
  
Property and equipment
    
17,516
      
14,038
  
Less accumulated depreciation
    
(9,723
 )    
(7,754
 )
Property and equipment, net
   $
7,793
     $
6,284