Stock-Based Compensation - Summary of Stock Incentive Plans (Details) - USD ($) $ / shares in Units, $ in Thousands			1 Months Ended	12 Months Ended
	Jun. 16, 2020	May 12, 2015	Nov. 30, 2013	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Apr. 13, 2022	Apr. 12, 2022
Stock-Based Compensation
Incentive stock option term		10 years
Option outstanding				26,533	31,221
Options available for grant under stock option plans				122,978	8,417
Common stock reserved for issuance				203,427	55,715
Shares Available for Grant
Beginning balance (in shares)				8,417
Ending balance (in shares)				122,978	8,417
Stock Options Outstanding
Beginning balance (in shares)				31,221
Ending balance (in shares)				26,533	31,221
RSUs Outstanding
Beginning balance (in shares)				6,499
Ending balance (in shares)				44,865	6,499
Options vested, exercisable and expected to vest
Weighted average grant date fair value of stock options granted (in dollars per share)				$ 22.04	$ 379.66
Number of options vested (in shares)				7,492	9,280
Weighted average fair value of options vested on grant date				$ 304.57	$ 336.60
Stock options
Stock-Based Compensation
Option outstanding				28,079	33,286	20,229
Stock Options Outstanding
Beginning balance (in shares)				33,286	20,229
Options granted (in shares)				44	13,547
Options exercised (in shares)				0	(42)
Options cancelled (in shares)				(5,251)	(448)
Ending balance (in shares)				28,079	33,286	20,229
Weighted Average Stock Option Exercise Price
Beginning balance (in dollars per share)				$ 707.97	$ 950.90
Options granted (in dollars per share)				23.46	405.45
Options exercised (in dollars per share)					100.35
Options cancelled (in dollars per share)				418.34	2,285.32
Ending balance (in dollars per share)				$ 592.73	$ 707.97	$ 950.90
Weighted Average Remaining Contractual Life (Years)
Weighted Average Remaining Contractual Life (Years)				7 years 2 months 8 days	8 years 4 months 6 days	8 years 8 months 15 days
Options vested, exercisable and expected to vest
Options vested and exercisable (in shares)				26,102
Options vested and exercisable (in dollars per share)				$ 614.51
Options vested and exercisable (in years)				7 years 1 month 9 days
Options vested and expected to vest (in shares)				27,901
Options vested and expected to vest (in dollars per share)				$ 594.38
Options vested and expected to vest (in years)				7 years 2 months 4 days
Aggregate Intrinsic Value ,outstanding					$ 3	$ 364
Options exercised (in shares)				0	42
Stock options and RSUs
Stock-Based Compensation
Options available for grant under stock option plans				122,978	8,417	2,652
Shares Available for Grant
Beginning balance (in shares)				8,417	2,652
Additional shares authorized (in shares)				151,079	25,358
Options granted (in shares)				(44)	(13,547)
Options cancelled (in shares)				5,251	448
Ending balance (in shares)				122,978	8,417	2,652
RSUs Outstanding
RSUs Granted (in shares)				41,725	6,494
Restricted stock units issued and outstanding
Shares Available for Grant
RSUs vested and released (in shares)				(2,516)
RSUs Outstanding
Beginning balance (in shares)				6,499	5
RSUs Granted (in shares)				41,725	6,494
RSUs vested and released (in shares)				(2,516)
RSUs Cancelled (in shares)				(843)
Ending balance (in shares)				44,865	6,499	5
2013 Plan
Stock-Based Compensation
Option shares outstanding				2	2
2013 Plan | Stock options
Stock Options Outstanding
Options granted (in shares)			0
2014 Plan
Stock-Based Compensation
Option outstanding				26,533	31,740
Options available for grant under stock option plans				116,011	8,260
Common stock reserved for issuance							2,417,660
Shares Available for Grant
Beginning balance (in shares)				8,260
Ending balance (in shares)				116,011	8,260
Stock Options Outstanding
Beginning balance (in shares)				31,740
Ending balance (in shares)				26,533	31,740
2014 Plan | Stock options
Stock-Based Compensation
Increase in share reserve based on outstanding number of shares (as a percent)		2.00%
2020 New Employee Inducement Award Plan
Stock-Based Compensation
Incentive stock option term	10 years
Option outstanding				1,546	1,546
Options available for grant under stock option plans	2,222			6,967	157
Shares Available for Grant
Beginning balance (in shares)				157
Additional shares authorized (in shares)				151,079
Ending balance (in shares)	2,222			6,967	157
Stock Options Outstanding
Beginning balance (in shares)				1,546
Ending balance (in shares)				1,546	1,546
Inducement Award Plan
Stock-Based Compensation
Common stock reserved for issuance							471,833
Number of shares reserved for issuance							971,833	500,000
Common Stock
Options vested, exercisable and expected to vest
Share Price				$ 6.52
Participants Voting Power More than Ten Percent | 2014 Plan
Stock-Based Compensation
Incentive stock option term		5 years
Participants Voting Power More than Ten Percent | 2020 New Employee Inducement Award Plan
Stock-Based Compensation
Incentive stock option term	5 years