Stock Based Compensation - Summary of Stock Incentive Plans (Details) - USD ($)			12 Months Ended
	Jun. 16, 2020	May 12, 2015	Dec. 31, 2021	Dec. 31, 2020	Mar. 31, 2020
Stock Based Compensation
Incentive stock option term		P10Y
Option outstanding			2,348,199	1,485,518
Options available for grant under stock option plans			631,270	198,866
Shares Available for Grant
Beginning balance (in shares)			198,866
Ending balance (in shares)			631,270	198,866
Stock Options Outstanding
Beginning balance (in shares)			1,485,518
Ending balance (in shares)			2,348,199	1,485,518
RSUs Outstanding
Beginning balance (in shares)			1,871
Ending balance (in shares)			487,456	1,871
Options vested, exercisable and expected to vest
Share Price					$ 1.31
Weighted average grant date fair value of stock options granted (in dollars per share)			$ 5.06	$ 1.20
Number of options vested (in shares)			695,995	483,021
Common Stock, Capital Shares Reserved for Future Issuance			4,185,269	4,126,362
Weighted average fair value of options vested on grant date			$ 4.49	$ 5.97
Stock options
Stock Based Compensation
Option outstanding			2,503,075	1,523,790
Stock Options Outstanding
Beginning balance (in shares)			1,523,790
Options granted (in shares)			1,016,044
Options exercised (in shares)			(3,147)	(185)
Options cancelled (in shares)			(33,612)
Ending balance (in shares)			2,503,075	1,523,790
Weighted Average Stock Option Exercise Price
Beginning balance (in dollars per share)			$ 12.68
Options granted (in dollars per share)			5.41
Options exercised (in dollars per share)			1.34
Options cancelled (in dollars per share)			30.47
Ending balance (in dollars per share)			$ 9.44	$ 12.68
Weighted Average Remaining Contractual Life (Years)
Weighted Average Remaining Contractual Life (Years)			8 years 4 months 6 days	8 years 8 months 15 days
Options vested, exercisable and expected to vest
Options vested and exercisable (in shares)			1,431,658
Options vested and exercisable (in dollars per share)			$ 12.92
Options vested and exercisable (in years)			7 years 10 months 2 days
Options vested and expected to vest (in shares)			2,362,310
Options vested and expected to vest (in dollars per share)			$ 9.70
Options vested and expected to vest (in years)			8 years 3 months 18 days
Options exercised (in shares)			3,147	185
Aggregate Intrinsic Value ,outstanding			$ 3	$ 364,000
Aggregate Intrinsic Value, Exercisable			2,000
Aggregate Intrinsic Value, Vested and expected to vest			$ 3,000
Inducement options issued and outstanding
Stock Based Compensation
Option outstanding			154,893	38,289
Stock Options Outstanding
Beginning balance (in shares)			38,289
Ending balance (in shares)			154,893	38,289
Stock options and RSUs
Stock Based Compensation
Options available for grant under stock option plans			631,270	198,866
Shares Available for Grant
Beginning balance (in shares)			198,866
Additional shares authorized (in shares)			1,900,421
Options granted (in shares)			(1,016,044)
Options cancelled (in shares)			33,612
Ending balance (in shares)			631,270	198,866
Restricted stock units issued and outstanding
Shares Available for Grant
Options cancelled (in shares)			(485,585)
RSUs Outstanding
Beginning balance (in shares)			1,871
RSUs Granted (in shares)			485,585
Ending balance (in shares)			487,456	1,871
2013 Plan
Stock Based Compensation
Option shares outstanding			123	123
2013 Plan | Stock options
Stock Options Outstanding
Options granted (in shares)			0
2014 Plan
Stock Based Compensation
Option outstanding			2,348,076	1,485,395
Options available for grant under stock option plans			619,480	70,472
Shares Available for Grant
Beginning balance (in shares)			70,472
Ending balance (in shares)			619,480	70,472
Stock Options Outstanding
Beginning balance (in shares)			1,485,395
Ending balance (in shares)			2,348,076	1,485,395
2014 Plan | Stock options
Stock Based Compensation
Increase in share reserve based on outstanding number of shares (as a percent)		2.00%
2020 New Employee Inducement Award Plan
Stock Based Compensation
Incentive stock option term	P10Y
Option outstanding			154,876	38,272
Options available for grant under stock option plans	166,666		11,790	128,394
Shares Available for Grant
Beginning balance (in shares)			128,394
Ending balance (in shares)	166,666		11,790	128,394
Stock Options Outstanding
Beginning balance (in shares)			38,272
Ending balance (in shares)			154,876	38,272
Common Stock
Options vested, exercisable and expected to vest
Share Price			$ 1.04
Participants Voting Power More than Ten Percent | 2014 Plan
Stock Based Compensation
Incentive stock option term		P5Y
Participants Voting Power More than Ten Percent | 2020 New Employee Inducement Award Plan
Stock Based Compensation
Incentive stock option term	P5Y