Capped percentage of aggregate default.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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The amount of cash outflow for payment of transaction fee under accounts receivable purchase agreement.

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Percentage of default effect for each occurrence of default.

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- Definition

Percentage of gross proceeds received from the sale of Tropical Disease Priority Review voucher, the return bonus.

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Percentage of outstanding balance payable on which the company elects to prepay.

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Percentage of reduction in return bonus.

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Percentage of return bonus payable.

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The aggregate purchase price of royalty for the entity.

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Term for initiation of human trials.

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The amount of expenses incurred in connection with transaction cost.

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Amount, before unamortized (discount) premium and debt issuance costs, of long-term debt. Includes, but is not limited to, notes payable, bonds payable, commercial loans, mortgage loans, convertible debt, subordinated debt and other types of debt.

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Face (par) amount of debt instrument at time of issuance.

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Contractual interest rate for funds borrowed, under the debt agreement.

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Period of time between issuance and maturity of debt instrument, in PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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For each line item in the statement of financial position, the amounts of gains and losses from fair value changes included in earnings.

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Difference between the fair value of payments made and the carrying amount of debt which is extinguished prior to maturity.

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Fair value portion of notes payable.

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The cash inflow from a borrowing supported by a written promise to pay an obligation.

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Debt - Streeterville Note (Details)			1 Months Ended	12 Months Ended
Debt - Streeterville Note (Details)	Jan. 13, 2021 USD ($)	Jul. 01, 2020	Jan. 31, 2021 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Debt
Proceeds from issuance of notes payable, net of issuance costs of $50 in 2021 and 2020				$ 10,975,000	$ 12,300,000
Long-term Debt, Gross				6,000,000
Loss on extinguishment of debt			$ (753,000)	753,000	1,864,000
Cash proceeds				10,975,000	12,300,000
Fair value				7,818,000	$ 0
Streeterville Note
Debt
Principal amount	$ 6,200,000
Aggregate purchase price	$ 6,000,000.0
Proceeds from issuance of notes payable, net of issuance costs of $50 in 2021 and 2020				$ 6,000,000.0
Debt Instrument, Term	4 years
Percentage of Return Bonus Payable		1
Percentage of Reduction in Return Bonus			1
Interest rate (as a percent)	3.25%
Term for Initiation of Human Trials			6 months
Percentage of Outstanding Balance Payable the Company Elects to Prepay				112.5
Capped percentage of aggregate default	25.00%
Cash proceeds				$ 6,000,000.0
Transaction expense				25,000
Fair value				7,800,000
Net increase in the Fair value recorded as loss				$ 1,800,000
Streeterville Note \| Maximum
Debt
Percentage of Gross Proceeds Received from Return Bonus				18
Interest rate (as a percent)	18.00%
Percentage of default effect	15.00%
Streeterville Note \| Minimum
Debt
Interest rate (as a percent)				1.00%
Percentage of default effect	5.00%
Accounts Receivable Purchase Agreement \| Streeterville Note
Debt
Interest rate (as a percent)	25.00%
Payment Of Transaction Fee	$ 25,000