CONSOLIDATED STATEMENTS OF CHANGES IN CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' EQUITY - USD ($)	Series 1 warrants Common Stock Common stock - voting	Series 1 warrants Additional paid-in capital	Series 1 warrants	Series 1 warrants Common Stock Common stock - voting	Series 1 warrants Additional paid-in capital	Series 1 warrants	Series 2 warrants Additional paid-in capital	Series 2 warrants	Series 3 warrants Additional paid-in capital	Series 3 warrants Common stock - voting	Series 3 warrants	Series 1 and Series 2 warrants Additional paid-in capital	Series 1 and Series 2 warrants Common stock - voting	Series 1 and Series 2 warrants	Series 1, Series 2, and 2019 Bridge Note warrants Additional paid-in capital	Series 1, Series 2, and 2019 Bridge Note warrants Common stock - voting	Series 1, Series 2, and 2019 Bridge Note warrants	Series 1, Series 2, and 2019 Bridge Note warrants May 2020 Additional paid-in capital	Series 1, Series 2, and 2019 Bridge Note warrants May 2020 Common stock - voting	Series 1, Series 2, and 2019 Bridge Note warrants May 2020	Series 1, Series 2, and 2019 Bridge Note warrants June 2020 Additional paid-in capital	Series 1, Series 2, and 2019 Bridge Note warrants June 2020 Common stock - voting	Series 1, Series 2, and 2019 Bridge Note warrants June 2020	Series 2 warrants and inducement offer conversion of Series B-1 convertible preferred stock Additional paid-in capital	Series 2 warrants and inducement offer conversion of Series B-1 convertible preferred stock Common stock - voting	Series 2 warrants and inducement offer conversion of Series B-1 convertible preferred stock	Series B-1 convertible preferred stock Additional paid-in capital	Series B-1 convertible preferred stock	Series B-2 convertible preferred stock Common Stock Common stock - voting	Series B-2 convertible preferred stock Additional paid-in capital	Series B-2 convertible preferred stock Series B-2 convertible preferred stock	Series B convertible preferred stock Common Stock Common stock - voting	Series B convertible preferred stock Additional paid-in capital	Series B convertible preferred stock Series B-1 convertible preferred stock	Series B convertible preferred stock	Series C perpetual preferred stock Additional paid-in capital Series C perpetual preferred stock	Series C perpetual preferred stock Additional paid-in capital	Series C perpetual preferred stock Series C perpetual preferred stock	Series C perpetual preferred stock Common stock - voting	PIPE Financing Warrants, Dec 2019 Common Stock Common stock - voting	PIPE Financing Warrants, Dec 2019 Additional paid-in capital	PIPE Financing Warrants, Dec 2019 Common stock - voting	PIPE Financing Warrants, Dec 2019	Bridge Note Warrants Additional paid-in capital	Bridge Note Warrants	LOC warrant Additional paid-in capital	LOC warrant	March 2019 registered offering Common Stock Common stock - voting	March 2019 registered offering Additional paid-in capital	March 2019 registered offering	March 2020 Equity Purchase Agreement Additional paid-in capital	March 2020 Equity Purchase Agreement Common stock - voting	March 2020 Equity Purchase Agreement	Private placement Common Stock Common stock - voting	Underwriter Settlement Agreement Additional paid-in capital	Underwriter Settlement Agreement Common stock - voting	Underwriter Settlement Agreement	At The Market Offering	Registered Direct Offering Additional paid-in capital	Registered Direct Offering Common stock - voting	Registered Direct Offering	CVP Exchange Notes Common Stock Common stock - voting	CVP Exchange Notes Additional paid-in capital	CVP Exchange Notes Common stock - voting	CVP Exchange Notes	Common Stock Common stock - voting Tempesta	Common Stock Common stock - voting	Common Stock Common stock - non-voting	Additional paid-in capital Series B convertible preferred stock	Additional paid-in capital Series B-1 convertible preferred stock	Additional paid-in capital Series C perpetual preferred stock	Additional paid-in capital Series B-1 preferred - Ionic (Oct 2, 2019)	Additional paid-in capital Series D perpetual preferred stock	Additional paid-in capital Tempesta	Additional paid-in capital Atlas	Additional paid-in capital PoC Capital, LLC	Additional paid-in capital Pacific Capital Management LLC	Additional paid-in capital	Accumulated deficit	Series A convertible preferred stock	Series B convertible preferred stock	Series B-1 convertible preferred stock	Series B-2 convertible preferred stock	Series C perpetual preferred stock	Series B-1 preferred - Ionic (Oct 2, 2019)	Common stock - voting Atlas	Common stock - voting PoC Capital, LLC	Common stock - voting Pacific Capital Management LLC	Common stock - voting	Common stock - non-voting	Series D perpetual preferred stock	Tempesta	Atlas	PoC Capital, LLC	Pacific Capital Management LLC	Total
Beginning Balance at Dec. 31, 2018																																																																																$ 9,000,000
Beginning Balance (in shares) at Dec. 31, 2018																																																																																5,524,926
Increase (decrease) in temporary equity
Accretion to redemption value of redeemable preferred stock																																																																																$ 895,000
Ending Balance at Dec. 31, 2019																																																																			$ 1,000	$ 4,000												$ 9,895,000	$ 476,000		$ 1,236,000
Ending Balance (in shares) at Dec. 31, 2019																																																																																5,524,926	1,971		10,165								0
Beginning Balance at Dec. 31, 2018																																																																				$ 4,000										$ 99,930,000	$ (94,551,000)																	$ 5,383,000
Beginning Balance (in shares) at Dec. 31, 2018																																																																			351,472	40,301,237
Increase (decrease) in Stockholders' Equity (Deficit)
Deemed dividend on the Series B convertible preferred stock																																																																														(4,240,000)			$ 4,240,000
Deemed dividend attributable to Series 1 warrant modification																																																																						$ (530,000)								(522,000)				$ 530,000														(522,000)
Issuance of common stock in Class A Units, net																																																																														1,394,000																		1,394,000
Issuance of common stock in Class A Units, net (in shares)																																																																			2,886,500
Issuance costs from issuance of Series B-1 preferred stock, October 2019																											$ (20,000)	$ (20,000)
Issuance of common stock, net of offering costs, put exercise																																																																														2,602,000																		2,602,000
Issuance of common stock, net of offering costs, put exercise (in shares)																																																																			195,319
Issuance of common stock in exchange for services																																																																														140,000																		140,000
Issuance of common stock in exchange for services (in shares)																																																																			166,667
Issuance of common stock, registered offering																																																	$ 266,000	$ 266,000
Issuance of common stock, registered offering (in shares)																																																19,019
Issuance of prepaid equity forward contracts, November 2019																																																																														1,713,000																		1,713,000
Issuance of common stock upon settlement of prepaid equity forward contracts,																														$ (1,236,000)	$ 1,236,000																																															10,000																		10,000
Issuance of common stock upon settlement of prepaid equity forward contracts, November 2019 (in shares)																													(695,127)		10,165																																				986,000
Issuance of common stock in exchange of notes payable and accrued interest																																																																			$ (1,000)											(8,223,000)																		(8,224,000)
Issuance of common stock in exchange of notes payable and accrued interest (in shares)																																																																			395,970
Issuance of common stock upon conversion of Series B convertible preferred stock																																																																					$ (2,129,000)												2,129,000
Issuance of common stock in exchange of notes payable																																																															$ 6,673,000		$ 6,673,000									$ 49,000																		$ 49,000
Issuance of common stock in exchange of notes payable (in shares)																																																														1,119,440				40,000
Beneficial conversion feature of convertible preferred stock																																																																					$ 4,240,000	$ 530,000											$ (4,240,000)	$ (530,000)
Issuance of warrants		$ 5,026,000	$ 5,026,000				$ 5,026,000	$ 5,026,000																																	$ 465,000		$ 465,000
Modification of warrants																																																																														522,000																		522,000
Warrant reclassification from liability to equity																																												$ 4,259,000	$ 4,259,000	$ 71,000	$ 71,000
Accretion to redemption value of redeemable preferred stock																																																																														(895,000)																		(895,000)
Fractional shares (in shares)																																																																			(14)
Issuance of common stock in exchange of accrued interest, January 2019																																																																														447,000																		$ 447,000
Issuance of common stock in exchange of accrued interest, January 2019 (in shares)																																																						19,752
Issuance of common stock																																									1,035,000		1,035,000																													$ (530,000)													$ 530,000
Issuance of common stock (In shares)																																								2,500,000																																													63
Conversion of Series B convertible preferred stock into common stock																																	$ 531,000	$ (530,000)	$ 1,000
Conversion of Series B convertible preferred stock into common stock (shares)																																630,063		(63)																																	4,408,000														(8,816)		(190)
Issuance of Series B convertible preferred stock, net																																																																																	$ 2,605,000
Issuance of Series B convertible preferred stock, net (in shares)																																																																																	10,787
Issuance of common stock upon exercise of Series 1 warrants, October 2019		$ 389,000	$ 389,000		$ 1,360,000	$ 1,360,000
Issuance of common stock upon exercise of Series 1 warrants, October 2019(in shares)	277,774			972,226
Accretion to redemption value of Series A contingently redeemable convertible preferred stock																																																																																$ 894,000
Shares issued upon exercise of stock options (in shares)																																																																																																0
Stock-based compensation																																																																														2,989,000																		$ 2,989,000
Net loss																																																																															(38,539,000)																	(38,539,000)
Ending Balance at Dec. 31, 2019																																																																														142,046,000	(133,090,000)										$ 1,000	$ 4,000						10,673,000
Ending Balance (in shares) at Dec. 31, 2019																																																																			14,273,061	40,301,237																					14,273,061	40,301,237
Increase (decrease) in temporary equity
Series A convertible preferred stock redeemed and Series C perpetual preferred issued under the exchange transaction																																																																														150,000		$ (11,227,000)				$ 4,717,000												4,867,000
Series A convertible preferred stock redeemed and Series C perpetual preferred issued under the exchange transaction (in shares)																																																																																(5,524,926)				842,500
Accretion to redemption value of redeemable preferred stock																																																																																$ 1,332,000
Ending Balance (in shares) at Dec. 31, 2020																																																																																	0		0								0
Increase (decrease) in Stockholders' Equity (Deficit)
Deemed dividend attributable to Series 1 warrant modification															$ (856,000)		$ (856,000)																																																						$ (2,521,000)													$ 2,521,000
Issuance of warrants																																																							$ 31,000		$ 31,000
Issuance of common stock in exchange for services																																																			$ 33,000		$ 33,000																							$ 437,000											$ 1,333,333							$ 437,000
Issuance of common stock in exchange for services (in shares)																																																				68,807
Shares issued to Iliad in exchange of Royalty Interest																																																																														256,000																		256,000
Shares issued to Iliad in exchange of Royalty Interest (in shares)																																																																																									1,314,974
Shares issued on exchange of Series perpetual preferred stock																																					$ 4,846,000	$ (4,847,000)	$ 1,000																																		$ 7,875,000																$ 2,000		$ 7,877,000
Shares issued on exchange of Series perpetual preferred stock (Shares)																																						(858,810)	8,453,880																																																				15,889,871
Shares issued to Atlas Sciences for settlement of Trial Delay Fee																																																																											$ 612,000																		$ 612,000
Shares issued to Atlas Sciences for settlement of Trial Delay Fee (in shares)																																																																																						2,000,000
Shares issued on conversion of warrants of Atlas for settlement of Trial Delay Fee																																				$ (1,000)			$ 1,000																																				$ 1,903,000		$ 24,000									$ 1,000							$ 1,904,000		$ 24,000
Shares issued on conversion of warrants of Atlas for settlement of Trial Delay Fee (in shares)																																							7,057,692																																															6,218,954		50,000
Extinguishment of Series C perpetual preferred stock																																																																							$ 2,521,000													(2,521,000)
Modification of warrants															856,000		856,000
Conversion of Series B-2 convertible preferred stock into common stock																																																																														1,236,000					$ (1,236,000)
Conversion of Series B-2 convertible preferred stock into common stock (in shares)																																																																																			(10,165)						2,246,286
Fractional shares (in shares)																																																																																									(190)
Value of shares issued on exercise of warrants									$ 6,056,000	$ 1,000	$ 6,057,000	$ 626,000		$ 626,000	$ 392,000		$ 392,000	$ 3,787,000	$ 1,000	$ 3,788,000	$ 359,000		$ 359,000	$ 2,340,000	$ 1,000	$ 2,341,000
Shares issued on exercise of warrants										8,456,352			1,279,266			548,962			8,670,852			732,315			1,250,000
Issuance of common stock																																									$ 668,000		$ 668,000												$ 45,000		$ 45,000		$ 1,207,000		$ 1,207,000
Issuance of common stock (In shares)																																										1,714,283														100,000		3,814,925		3,814,925
Underwriter settlement offering cost																																																																														(185,000)																		(185,000)
Conversion of Series B convertible preferred stock into common stock																																																			$ 10,000		$ 10,000																									476,000			$ (476,000)		$ (1,236,000)
Conversion of Series B convertible preferred stock into common stock (shares)																																																				52,000																													(1,971)	(10,001)							4,423,251
Shares issued in exchange of CVP Exchange Notes																																																															$ 6,511,000	$ 2,000	$ 6,513,000
Shares issued in exchange of CVP Exchange Notes (in shares)																																																																21,471,724
Stock dividend attributable to Series C perpetual preferred stock of $8 per share																																																																														(130,000)						$ 130,000
Stock dividend attributable to Series C perpetual preferred stock of $8 per share (in shares)																																																																																				16,310
Shares issued to third party for services																																																																														105,000																		105,000
Shares issued to third party for services (in shares)																																																																																									275,000
Shares issued to Sagard Capital in exchange of services																																																																														879,000																		879,000
Shares issued to Sagard Capital in exchange of services (in shares)																																																																																									2,289,474
Conversion of non-voting common stock to voting common stock																																																																														4,000												$ (4,000)
Conversion of non-voting common stock to voting common stock (Shares)																																																																																									36,361	(38,180,451)
Accretion to redemption value of Series A contingently redeemable convertible preferred stock																																																																														(1,332,000)		$ 1,332,000																$ (1,332,000)
Shares issued upon exercise of stock options (in shares)																																																																																									555							555
Stock-based compensation																																																																														2,824,000																		$ 2,824,000
Net loss																																																																															(33,809,000)																	(33,809,000)
Ending Balance at Dec. 31, 2020																																																																														$ 184,090,000	$ (166,899,000)										$ 11,000							$ 17,202,000
Ending Balance (in shares) at Dec. 31, 2020																																																																																									114,022,368	2,120,786