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Commitments and Contingencies - Commitments (Details)
12 Months Ended
Sep. 03, 2020
kg
Aug. 31, 2020
USD ($)
ft²
Aug. 28, 2018
USD ($)
ft²
shares
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Commitments and Contingencies            
Monthly base rent for first twelve months     $ 38,000      
Monthly base rent for subsequent twelve months     40,000      
Monthly base rent for final months     41,000      
Standby letter of credit received as collateral     $ 475,000      
Term     5 years      
Warrants to purchase (in shares) | shares     9,580      
Fair value of warrants included in stockholders equity     $ 494,000      
Minimum            
Commitments and Contingencies            
Lease expense under non-cancelable operating lease       $ 38,000    
Letter of credit            
Commitments and Contingencies            
Letter of Credit           $ 475,000
Letter of credit | Shareholder            
Commitments and Contingencies            
Letter of Credit           122,000
Letter of credit cancelled           $ 122,000
General and administrative expense            
Commitments and Contingencies            
Lease expense under non-cancelable operating lease       $ 633,000 $ 745,000  
Office lease extension agreement            
Commitments and Contingencies            
Area (in square feet) | ft²     6,311      
Office space sub lease            
Commitments and Contingencies            
Area (in square feet) | ft²   5,263        
Sub lease rent   $ 15,000        
Manufacturing and Supply Agreement with Glenmark Life Sciences Limited [Member]            
Commitments and Contingencies            
License agreement term (in years) 2 years 6 months          
Agreement extension term 2 years          
License termination term option 12 months          
License termination activated upon written notice of material breach of Agreement 90 days          
Manufacturing and Supply Agreement with Glenmark Life Sciences Limited [Member] | Minimum            
Commitments and Contingencies            
Number of kilograms of crofelemer per year per agreement | kg 300